1. Trauma and Fracture Management

1. A prospective randomized controlled trial comparing volar locking plate versus external fixation in distal radius fractures: functional scores and radiographic healing at 6 months

2. A retrospective cohort analysis of open reduction and internal fixation versus intramedullary nailing in tibial shaft fractures: union time and complication rates

3. An in vitro biomechanical study of locking compression plate versus dynamic compression plating in midshaft femur fractures: load-to-failure and stiffness measurements

4. A cross-sectional ultrasound evaluation of callus formation dynamics in non-operatively managed clavicle fractures

5. A retrospective histological assessment of osteogenic marker (osteocalcin, BMP-2) expression in nonunion fracture tissue biopsies

6. A case-control study of smoking status effects on fracture healing time and infection rates in operatively treated long bone fractures

7. A methodological validation of low-intensity pulsed ultrasound therapy for tibial fracture healing: CT volumetric callus analysis

8. A systematic review and meta-analysis of antibiotic cement-coated intramedullary nails in infected nonunions: infection control and functional outcomes

9. An in silico finite-element modeling study of stress distribution in proximal humerus fractures fixed with locking plates versus elastic nails

10. A narrative review of emerging biologics (BMPs, PRP) in augmentation of fracture healing: efficacy, safety, and clinical applications

2. Joint Replacement & Arthroplasty

1. A prospective cohort study of cemented versus cementless total hip arthroplasty in elderly patients: prosthesis migration and patient-reported outcome measures (PROMs)

2. A randomized controlled trial comparing kinematic alignment versus mechanical alignment in total knee arthroplasty: gait analysis and functional recovery

3. A retrospective analysis of periprosthetic joint infection rates in unicompartmental versus bicompartmental knee replacements: risk factors and outcomes

4. An in vitro wear simulator study comparing polyethylene liner wear in conventional versus highly cross-linked materials for hip implants

5. A case-control evaluation of ceramic-on-ceramic versus metal-on-polyethylene bearings in total hip replacements: osteolysis incidence and revision rates

6. A methodological validation of computer-assisted navigation versus conventional techniques in total knee arthroplasty: implant positioning accuracy

7. A systematic review and meta-analysis of tranexamic acid dosing protocols in arthroplasty: blood loss and transfusion requirements

8. An in silico optimization modeling of joint implant geometry to minimize stress shielding in femoral stems

9. A pilot prospective study of patient-specific 3D-printed cutting guides in unicompartmental knee arthroplasty: surgical time and alignment accuracy

10. A narrative review of next-generation implant coatings (antimicrobial, osteoinductive) for arthroplasty longevity

3. Spine Disorders & Surgery

1. A prospective randomized trial of minimally invasive tubular discectomy versus open microdiscectomy for lumbar disc herniation: pain relief and return-to-work time

2. A cross-sectional MRI-based morphometric analysis of spinal canal dimensions in lumbar spinal stenosis versus asymptomatic controls

3. A retrospective cohort study of pedicle screw loosening rates in osteoporotic versus non-osteoporotic patients undergoing lumbar fusion

4. An in vitro biomechanical comparison of expandable versus static interbody cages in porcine lumbar spine segments

5. A case-control evaluation of serum bone turnover markers (CTX, P1NP) and fusion success in posterior lumbar fusion patients

6. A methodological validation of intraoperative neuromonitoring thresholds for predicting postoperative neurologic deficits in spinal deformity correction

7. A systematic review and meta-analysis of tranexamic acid use in spine surgery: blood loss and complication profile

8. An in silico finite-element study of stress distribution in lumbosacral junction following varying fusion constructs

9. A pilot clinical trial of cell-based bone graft substitutes versus autograft in lumbar interbody fusion: radiographic fusion and functional outcomes

10. A narrative review of dynamic stabilization devices for degenerative lumbar spine disorders: biomechanical rationale and clinical evidence

4. Pediatric Orthopedics

1. A prospective cohort study of early versus delayed casting in pediatric distal radius buckle fractures: functional outcomes and complication rates

2. A randomized controlled trial of Pavlik harness versus rigid brace treatment in developmental dysplasia of the hip: success rates and avascular necrosis incidence

3. A cross-sectional gait analysis study in children with cerebral palsy pre- and post-single-event multilevel surgery

4. A retrospective review of surgical versus conservative management of slipped capital femoral epiphysis: long-term hip function and radiographic outcomes

5. An in vitro histological assessment of physeal plate injury models: chondrocyte viability and growth arrest phenomena

6. A case-control study of vitamin D deficiency prevalence in children presenting with rickets versus healthy peers: biochemical and radiographic correlation

7. A methodological validation of ultrasound for early detection of neonatal hip instability compared to radiographic assessment

8. A systematic review and meta-analysis of outcome measures in pediatric scoliosis correction: growth-friendly versus definitive fusion techniques

9. An in silico growth modulation modeling of guided growth plates for angular deformity correction in pediatric patients

10. A narrative review of tissue-engineered cartilage grafts for pediatric joint reconstruction: preclinical and clinical perspectives

5. Sports Medicine & Soft Tissue Injuries

1. A prospective randomized trial of platelet-rich plasma versus corticosteroid injection in chronic lateral epicondylitis: pain scores and tendon ultrasonography findings

2. A cross-sectional evaluation of isokinetic strength imbalances in athletes post–anterior cruciate ligament reconstruction

3. A retrospective cohort analysis of return-to-play timing and re-injury rates after rotator cuff repair in overhead athletes

4. An in vitro mechanical testing of novel scaffold materials for rotator cuff tendon-to-bone healing: load-to-failure properties

5. A case-control study of serum biomarkers (COMP, MMP-3) in early versus late osteoarthritis in professional athletes

6. A methodological validation of inertial sensor–based gait analysis versus motion-capture systems in detecting lower limb kinematic abnormalities

7. A systematic review and meta-analysis of functional bracing versus surgical fixation for acute ACL injuries: outcomes and complications

8. An in silico finite-element modeling of ligament strain patterns in different shoulder stabilization techniques

9. A pilot trial of stem cell–seeded scaffolds for meniscal regeneration in a goat model: histological and biomechanical assessment

10. A narrative review of rehabilitation protocols and criteria for safe return to sport after hamstring strain injuries

6. Bone Biology & Metabolic Bone Disease

1. A prospective observational study of bone mineral density changes and fracture risk in postmenopausal women on bisphosphonate therapy: DXA and FRAX analysis

2. A randomized trial of teriparatide versus denosumab in glucocorticoid-induced osteoporosis: bone turnover markers and BMD outcomes

3. A cross-sectional study correlating serum sclerostin levels with cortical bone microarchitecture in elderly men and women

4. An in vitro osteoblast differentiation assay evaluating the effects of novel Wnt pathway modulators

5. A case-control genetic association study of vitamin D receptor polymorphisms in patients with osteomalacia versus healthy controls

6. A methodological validation of high-resolution peripheral quantitative CT for assessment of trabecular bone microarchitecture compared to DXA

7. A systematic review and meta-analysis of calcium and vitamin D supplementation regimens on fall prevention in older adults

8. An in silico network analysis of signaling pathways implicated in osteoarthritis progression for drug target identification

9. A pilot clinical trial of romosozumab in fracture healing after nonunion surgery: radiographic and functional endpoints

10. A narrative review of emerging senolytic therapies for age-related bone loss and skeletal frailty

7. Orthopedic Oncology

1. A retrospective cohort study of limb salvage surgery versus amputation in osteosarcoma: survival rates and functional outcomes

2. A prospective observational analysis of circulating tumour DNA levels as biomarkers for recurrence in Ewing sarcoma patients

3. A case-control evaluation of pain and quality-of-life indicators in patients with benign versus malignant bone tumors

4. An in vitro chemosensitivity assay of patient-derived chondrosarcoma cell lines to novel tyrosine kinase inhibitors

5. A methodological validation of MRI radiomics in differentiating enchondroma from low-grade chondrosarcoma

6. A systematic review and meta-analysis of outcomes following expandable prosthesis reconstruction in pediatric bone malignancies

7. An in silico docking study of small-molecule inhibitors targeting the MDM2–p53 interaction in soft tissue sarcomas

8. A pilot clinical trial of immune checkpoint inhibitor therapy in refractory osteosarcoma: safety and preliminary efficacy

9. A retrospective analysis of local recurrence predictors following wide resection of high-grade sarcomas around the knee

10. A narrative review of targeted radiopharmaceuticals for bone metastasis management

8. Foot and Ankle Surgery

1. A prospective randomized trial of plantar fascia release versus corticosteroid injection in chronic plantar fasciitis: pain relief and functional scores

2. A cross-sectional weight-bearing CT assessment of hallux valgus deformity severity versus radiographic angles

3. A retrospective cohort study comparing fusion rates in ankle arthrodesis using iliac crest autograft versus synthetic bone substitute

4. An in vitro biomechanical comparison of locking plate versus intramedullary screw fixation in Jones fractures of the fifth metatarsal

5. A case-control study of serum uric acid levels and tophi burden in patients with gouty versus non-gouty foot arthritis

6. A methodological validation of pedobarography for pressure distribution analysis in diabetic versus non-diabetic neuropathic feet

7. A systematic review and meta-analysis of flexible versus rigid fixation techniques for syndesmosis injuries

8. An in silico finite-element modeling of stress distribution in posterior tibial tendon dysfunction after various osteotomy procedures

9. A pilot trial of platelet-rich fibrin membrane application in chronic diabetic foot ulcers: healing rate and histological evaluation

10. A narrative review of emerging minimally invasive techniques for correction of adult acquired flatfoot deformity

9. Upper Extremity Disorders

1. A randomized controlled trial comparing arthroscopic versus open repair of rotator cuff tears: functional and radiologic outcomes

2. A cross-sectional nerve conduction study of median nerve parameters in carpal tunnel syndrome patients versus healthy controls

3. A retrospective cohort analysis of volar versus dorsal plating in distal radius fractures: complication rates and wrist motion

4. An in vitro tensile testing of suture anchor pullout strength in osteoporotic versus healthy cadaveric humeral heads

5. A case-control evaluation of serum inflammatory cytokines (IL-6, TNF-α) in patients with tenosynovitis versus controls

6. A methodological validation of ultrasound elastography for assessing tendon healing after flexor tendon repair

7. A systematic review and meta-analysis of conservative versus surgical management of lateral epicondylalgia

8. An in silico finite-element modeling of distal radius plate configurations for optimized fixation stability

9. A pilot clinical trial of autologous stem cell injections for refractory lateral epicondylitis: pain scores and imaging findings

10. A narrative review of advances in nerve regeneration conduits for peripheral nerve injuries

10. Recent Advances in Orthopedics

1. A scoping review of 3D bioprinted bone and cartilage constructs for musculoskeletal tissue engineering

2. A prospective pilot study of surgeon learning curves and accuracy using augmented reality navigation in complex orthopedic surgeries

3. A methodological assessment of wearable inertial sensor systems for in-home monitoring of gait and balance in post-arthroplasty patients

4. An in vitro validation of nanoparticle-mediated drug delivery systems for localized osteomyelitis treatment in bone explants

5. An in silico multi-omics integration approach to identify biomarkers for early diagnosis of osteoarthritis

6. A systematic review and meta-analysis of robotic-assisted orthopedic surgeries: indications, outcomes, and cost-effectiveness

7. A pilot clinical trial of gene therapy using BMP-2 plasmid delivery for nonunion fracture treatment

8. A retrospective data-mining analysis of electronic health records to predict perioperative complications in joint arthroplasty

9. A narrative review of CRISPR-Cas9 genome editing applications for hereditary musculoskeletal disorders

10. An exploratory study of bioresorbable metal implants (magnesium alloy) for fracture fixation: preclinical to early clinical data