Endocrinology Thesis Topics

Endocrinology Thesis Topics

Endocrinology is a broad superspeciality that covers diabetes mellitus, thyroid disease, adrenal and pituitary disorders, reproductive endocrinology, obesity, bone and mineral metabolism, endocrine hypertension and endocrine malignancies. This page provides a structured list of one hundred practical Endocrinology thesis topics suitable for DM Endocrinology thesis topics in India, endocrine dissertation topics for superspeciality residents, and Arab Board or GCC endocrinology research projects. The titles are framed as observational, cross sectional, and comparative studies that can be feasibly completed in tertiary care hospitals and teaching centres, with realistic sample sizes and routinely available investigations.

Whether you are searching for Endocrinology thesis topics for DM residents in India, Gulf Cooperation Council (GCC) endocrinology research topics for trainees in UAE, Saudi Arabia, Qatar, Kuwait, Oman and Bahrain, or Arab Board Endocrinology dissertation ideas, these clinically relevant and publication oriented titles are designed to match the case mix of real world endocrine and diabetes clinics in South Asia and the Middle East.

1. Diabetes Mellitus and Metabolic Disorders

Prospective observational study of clinical profile, complications, and treatment patterns in adults with type 2 diabetes mellitus attending a tertiary care endocrinology clinic. This thesis describes age at onset, duration of disease, glycaemic control, microvascular and macrovascular complications, and current pharmacotherapy in a real world cohort of type 2 diabetes patients.
Comparative study of glycaemic control and hypoglycaemia risk with different basal insulin regimens in type 2 diabetes mellitus. The project compares improvement in glycated haemoglobin, frequency of documented hypoglycaemia, weight change, and treatment satisfaction in patients switched to various basal insulin preparations in routine practice.
Cross sectional analysis of metabolic syndrome components in patients with type 2 diabetes mellitus in an Indian or GCC tertiary hospital. This research evaluates prevalence of obesity, dyslipidaemia, hypertension, and central adiposity in diabetes, and examines their association with cardiovascular risk markers.
Study of microalbuminuria and diabetic kidney disease in patients with recently diagnosed and long standing type 2 diabetes mellitus. The thesis compares prevalence and severity of albuminuria, estimated glomerular filtration rate, and risk factors such as blood pressure control and glycaemic status in early versus established diabetes.
Observational study of diabetic foot disease: risk factors, microbiological profile, and outcomes in a multidisciplinary foot clinic. This project evaluates peripheral neuropathy, peripheral arterial disease, ulcer characteristics, infecting organisms, need for hospitalisation or amputation, and healing rates in patients with diabetic foot complications.
Study of prevalence and predictors of diabetic retinopathy in type 2 diabetes mellitus patients undergoing routine screening. The research uses fundus examination or retinal photography to classify retinopathy stages and analyses associations with duration of diabetes, glycaemic control, blood pressure, and kidney involvement.
Cross sectional study of depression, diabetes distress, and quality of life in adults living with type 2 diabetes mellitus. This thesis uses validated questionnaires to assess emotional burden, regimen related distress, and overall health related quality of life and explores their relationship with clinical and demographic factors.
Observational study of type 1 diabetes mellitus in children and young adults attending an endocrinology clinic. The project describes age at diagnosis, family history, insulin regimens, acute complications such as ketoacidosis, and challenges in self management in patients with type 1 diabetes.
Study of lipid abnormalities and non alcoholic fatty liver disease in patients with type 2 diabetes mellitus. This research evaluates patterns of dyslipidaemia, hepatic ultrasound findings where performed, and association between liver steatosis, insulin resistance, and cardiovascular risk.
Prospective observational study of diabetic ketoacidosis and hyperosmolar hyperglycaemic state in adults admitted to a tertiary care hospital. The thesis describes precipitating factors, biochemical profile, treatment protocols, complications, and in hospital outcomes in patients presenting with acute metabolic decompensation of diabetes.

2. Thyroid Disorders

Cross sectional study of clinical and biochemical profile of hypothyroidism in adults presenting to an endocrinology clinic. This thesis evaluates symptoms, physical findings, thyroid stimulating hormone and free thyroxine levels, thyroid autoantibodies, and associated comorbidities such as dyslipidaemia and anaemia.
Comparative study of subclinical and overt hypothyroidism with respect to metabolic parameters and quality of life. The project compares lipid profile, weight, blood pressure, fatigue, and other quality of life scores between individuals with subclinical and overt hypothyroidism and euthyroid controls.
Observational study of Graves disease: clinical presentation, antibody status, and response to antithyroid drug therapy. This research documents symptom profile, ophthalmopathy, thyroid receptor antibody levels where available, duration of therapy, relapse rates, and predictors of remission in Graves disease.
Study of multinodular goitre and solitary thyroid nodules: ultrasound characteristics, fine needle aspiration findings, and histopathology correlation. The thesis analyses clinical and sonographic features, cytology reports, and surgical histopathology to assess the diagnostic performance of non invasive evaluation of thyroid nodules.
Cross sectional analysis of thyroid dysfunction in pregnancy and its maternal and fetal outcomes. This project evaluates prevalence of overt and subclinical hypothyroidism and hyperthyroidism in antenatal women, treatment provided, and outcomes such as miscarriage, preeclampsia, and neonatal complications.
Study of autoimmune thyroid disease: association with other autoimmune disorders and family history. The research describes coexistence of type 1 diabetes, pernicious anaemia, vitiligo, or other autoimmune diseases in patients with autoimmune thyroiditis or Graves disease and evaluates familial aggregation.
Observational study of radioiodine therapy outcomes in hyperthyroid patients where this modality is used. This thesis evaluates indications, dosing strategies, time to euthyroidism or hypothyroidism, need for repeat doses, and patient satisfaction after radioiodine treatment.
Study of subacute thyroiditis and other causes of painful thyroid swelling in a tertiary care setting. The project describes clinical presentation, laboratory and ultrasound findings, viral or post infectious associations, management, and outcomes of painful thyroid conditions.
Cross sectional study of thyroid function abnormalities in patients with chronic kidney disease, liver disease, or other systemic illnesses. This research examines patterns of altered thyroid hormone levels in non thyroidal illness and evaluates their clinical relevance in hospitalised patients.
Observational analysis of adherence to levothyroxine therapy and factors influencing adherence in hypothyroid patients. The thesis uses questionnaires to assess knowledge, beliefs, dosing practices, and barriers to regular medication use and correlates adherence with biochemical control.

3. Adrenal Disorders

Prospective observational study of adrenal insufficiency: primary, secondary, and tertiary forms in a tertiary care endocrinology clinic. This thesis describes clinical features, biochemical tests used for diagnosis, aetiology such as tuberculosis or autoimmune disease, and treatment regimens in adrenal insufficiency.
Study of adrenal crisis presentations in emergency and inpatient settings. The project evaluates precipitating factors, recognition and time to steroid administration, associated electrolyte abnormalities, and short term outcomes in adrenal crisis.
Cross sectional analysis of adrenal incidentalomas: clinical evaluation, imaging characteristics, and hormonal workup. This research describes size, imaging features, functional status, and decision making regarding surgery or surveillance in incidentally detected adrenal masses.
Study of Cushing syndrome: clinical features, diagnostic delays, and postoperative outcomes. The thesis documents symptom evolution, metabolic complications, diagnostic tests used, source localisation, and remission or recurrence rates after treatment.
Observational study of primary aldosteronism: screening, confirmatory tests, and subtype evaluation. This project evaluates hypertensive patients screened for primary aldosteronism, rates of positivity, confirmatory testing where performed, and imaging or adrenal vein sampling guided subtype classification.
Study of pheochromocytoma and paraganglioma: clinical spectrum, biochemical profile, and perioperative management. The research describes symptomatology, catecholamine levels, imaging modalities, preoperative alpha blockade, intraoperative haemodynamic events, and outcomes in catecholamine secreting tumours.
Cross sectional analysis of adrenal tuberculosis and other infectious causes of adrenal insufficiency in high prevalence regions. This thesis evaluates imaging findings, adrenal function tests, treatment, and recovery of adrenal function in infectious adrenal disease.
Study of glucocorticoid replacement regimens and quality of life in patients with chronic adrenal insufficiency. The project compares different dosing schedules where used, evaluates symptoms of under and over replacement, and assesses patient reported quality of life and satisfaction.
Observational study of adrenal involvement in critical illness and sepsis in intensive care patients. This research evaluates cortisol response tests where feasible, incidence of relative adrenal insufficiency, steroid use, and association with haemodynamic instability and outcomes.
Study of knowledge and practices related to stress dose steroids and emergency preparedness among patients with adrenal insufficiency. The thesis uses questionnaires to assess awareness of sick day rules, use of emergency steroid cards or injections, and adherence to medical advice in stressful situations.

4. Pituitary Disorders

Prospective observational study of pituitary adenomas: clinical presentation, hormonal profile, and imaging characteristics. This thesis documents functioning and non functioning adenomas, symptom duration, visual field defects, pituitary hormone hypersecretion and deficiency, and magnetic resonance imaging findings.
Study of acromegaly: diagnostic delay, comorbidities, and treatment outcomes in a tertiary care endocrinology centre. The project evaluates time from symptom onset to diagnosis, cardiovascular and metabolic complications, treatment modalities such as surgery and medical therapy, and biochemical remission rates.
Cross sectional analysis of prolactinomas: gender differences in clinical presentation and management. This research compares male and female patients regarding tumour size, hypogonadism, osteoporosis, response to dopamine agonists, and need for surgery.
Study of hypopituitarism: aetiology, pattern of hormone deficiencies, and replacement therapy practices. The thesis describes causes such as pituitary tumours, surgery, radiotherapy, and Sheehan syndrome, evaluates hormone deficits, and assesses adequacy and safety of hormone replacement.
Observational study of pituitary apoplexy: risk factors, clinical course, and visual and hormonal outcomes. This project evaluates predisposing conditions, acute presentation, timing of surgery or conservative management, and recovery of vision and pituitary function.
Study of non functioning pituitary macroadenomas managed by neurosurgery and endocrinology teams. The research describes preoperative status, surgical approach, complications, residual tumour, and long term need for hormone replacement and radiotherapy.
Cross sectional study of pituitary hormone abnormalities in patients with traumatic brain injury. This thesis evaluates prevalence of growth hormone, gonadotrophin, and other pituitary deficits after traumatic brain injury and explores correlation with injury severity and recovery.
Study of quality of life and psychological wellbeing in patients with pituitary disorders on long term follow up. The project uses validated questionnaires to assess physical, emotional, and social functioning and relates them to hormonal status and treatment history.
Observational study of incidental pituitary microadenomas detected on imaging for non endocrine indications. This research evaluates hormonal status, follow up imaging, and proportion with clinically significant progression needing intervention.
Study of central diabetes insipidus and disorders of water balance in patients with pituitary and hypothalamic disease. The thesis describes aetiology, diagnostic approach, desmopressin use, and challenges in managing fluid and electrolyte balance in these patients.

5. Reproductive and Gonadal Endocrinology

Cross sectional study of polycystic ovary syndrome in women attending an endocrinology or gynaecology clinic. This thesis evaluates diagnostic criteria, metabolic features such as insulin resistance and dyslipidaemia, menstrual irregularity, infertility, and psychosocial impact of polycystic ovary syndrome.
Study of hyperprolactinaemia and its reproductive consequences in women of reproductive age. The project analyses causes of elevated prolactin, menstrual disturbances, infertility, galactorrhoea, and response to medical therapy in women with hyperprolactinaemia.
Observational study of male hypogonadism: clinical features, hormonal profile, and aetiology. This research documents symptoms, testosterone and gonadotrophin levels, primary and secondary causes, and associated comorbidities such as metabolic syndrome and osteoporosis in men with hypogonadism.
Study of androgen excess states in women: clinical spectrum, biochemical abnormalities, and underlying diagnoses. The thesis describes hirsutism, acne, menstrual irregularity, serum androgen levels, and distribution of diagnoses such as polycystic ovary syndrome and non classical congenital adrenal hyperplasia.
Cross sectional analysis of premature ovarian insufficiency in women presenting to an endocrinology or infertility clinic. This project evaluates age at onset, aetiological investigations, family history, associated autoimmune disorders, and impact on reproductive choices and hormonal replacement.
Study of menstrual irregularities and endocrine abnormalities in adolescents attending an endocrine clinic. The research documents patterns of cycle disturbance, androgen levels, thyroid status, and other endocrine factors contributing to menstrual problems in adolescents.
Observational study of erectile dysfunction in men with diabetes mellitus and other endocrine disorders. This thesis assesses prevalence, severity scores, hormonal profile, vascular risk factors, and treatment patterns in men presenting with erectile dysfunction.
Study of infertility and endocrine abnormalities in couples evaluated in a joint endocrinology–reproductive medicine clinic. The project examines frequency of thyroid dysfunction, hyperprolactinaemia, polycystic ovary syndrome, and male endocrine factors in infertile couples and management outcomes.
Cross sectional analysis of hormonal changes during the menopausal transition and their relation to symptoms and metabolic risk. This research evaluates reproductive hormones, vasomotor symptoms, mood changes, bone health, and cardiovascular risk factors in perimenopausal and postmenopausal women.
Study of knowledge, attitudes, and practices regarding hormonal contraception and hormone replacement therapy among women with endocrine disorders. The thesis uses questionnaires to assess awareness, concerns, and usage patterns of hormonal therapies and identifies gaps in counselling in endocrine practice.

6. Obesity, Nutrition and Metabolic Syndrome

Cross sectional study of obesity and overweight in adults attending an endocrinology or diabetes clinic. This thesis evaluates body mass index, waist circumference, lifestyle factors, comorbid conditions, and readiness to change in patients with excess weight.
Study of metabolic syndrome prevalence in patients with type 2 diabetes mellitus and in non diabetic high risk individuals. The project compares frequency and clustering of metabolic syndrome components and cardiovascular risk markers in these two groups.
Observational study of non alcoholic fatty liver disease in obese and non obese individuals with metabolic risk factors. This research evaluates liver ultrasound findings, liver enzymes, insulin resistance, and association between fatty liver, visceral adiposity, and cardiometabolic risk.
Study of dietary patterns, physical activity, and sedentary behaviour in patients with obesity attending a weight management clinic. The thesis uses structured questionnaires to assess eating behaviour, exercise habits, and screen time and relates them to degree of obesity and metabolic complications.
Prospective observational study of outcomes of lifestyle intervention programmes in patients with obesity and metabolic syndrome. This project evaluates weight loss, waist circumference reduction, improvement in blood pressure, lipid profile, and glycaemic parameters after structured lifestyle modification.
Study of obstructive sleep apnoea risk and screening in adults with obesity and metabolic syndrome. The research assesses risk scores, sleep related symptoms, and, where available, polysomnography findings, and examines associations with blood pressure and glycaemic control.
Observational study of endocrine causes of obesity in patients referred to an endocrinology clinic. This thesis evaluates frequency of hypothyroidism, Cushing syndrome, hypothalamic disorders, and genetic conditions among individuals initially labelled as having primary obesity.
Study of body composition and sarcopenic obesity in middle aged and older adults with metabolic disorders. The project uses anthropometry or body composition assessments where available to examine low muscle mass with high fat mass and its relationship to functional status and metabolic risk.
Cross sectional analysis of stigma and psychosocial impact of obesity in patients seeking endocrine consultation. This research uses validated scales to assess weight related stigma, self esteem, depression, and quality of life in individuals living with obesity.
Study of pharmacological therapy for obesity in routine endocrinology practice where anti obesity medicines are available. The thesis evaluates indications, weight loss outcomes, tolerability, adherence, and metabolic benefits of anti obesity drugs used as part of comprehensive weight management.

7. Bone, Mineral Metabolism and Calcium Disorders

Cross sectional study of osteoporosis and osteopenia in postmenopausal women attending an endocrinology clinic. This thesis evaluates bone mineral density where available, fracture history, calcium and vitamin D intake, and risk factors such as early menopause and steroid use.
Study of secondary osteoporosis in men and premenopausal women with endocrine and systemic disorders. The project analyses frequency of low bone density and fractures in patients with hyperthyroidism, hypogonadism, Cushing syndrome, chronic inflammatory diseases, and glucocorticoid exposure.
Observational study of primary hyperparathyroidism: clinical presentation, biochemical profile, and skeletal and renal involvement. This research documents symptomatic and asymptomatic presentations, bone density, nephrolithiasis, and outcomes after parathyroid surgery where performed.
Study of hypocalcaemia and vitamin D deficiency in adults and children presenting to a tertiary care hospital. The thesis describes causes of low calcium, clinical manifestations such as tetany and seizures, vitamin D status, and response to treatment.
Cross sectional analysis of vitamin D status and its determinants in adults attending an endocrine clinic in India or GCC countries. This project evaluates serum vitamin D levels, sun exposure, dietary intake, clothing and cultural practices, and supplements use in the local population.
Study of fragility fractures and their endocrine and metabolic correlates in older adults. The research assesses fracture sites, prior falls, bone density, calcium and vitamin D levels, parathyroid hormone status, and current osteoporosis treatment.
Observational study of glucocorticoid induced osteoporosis prevention and treatment practices in endocrine and rheumatology clinics. This thesis evaluates risk assessment, prophylactic therapy, bone density testing, and adherence to guidelines in patients on long term glucocorticoids.
Study of hypoparathyroidism: aetiology, calcium and phosphate control, and quality of life. The project describes postsurgical and idiopathic hypoparathyroidism, management strategies using calcium and active vitamin D, complications such as nephrocalcinosis, and patient reported outcomes.
Cross sectional analysis of bone health in patients with type 1 and type 2 diabetes mellitus. This research evaluates bone mineral density where available, fracture history, and potential relationships between glycaemic control, microvascular complications, and skeletal health.
Study of awareness and treatment gaps in osteoporosis among patients with established fragility fractures. The thesis uses interviews and record review to assess how many fracture patients are evaluated and treated for underlying osteoporosis and identifies barriers to optimal care.

8. Endocrine Hypertension

Cross sectional study of secondary endocrine causes of hypertension in patients referred to an endocrinology clinic. This thesis evaluates prevalence of primary aldosteronism, pheochromocytoma, Cushing syndrome, thyroid disorders, and other endocrine conditions among patients with suspected secondary hypertension.
Study of screening for primary aldosteronism in resistant and early onset hypertension. The project analyses how many eligible patients are screened, rates of positive screening tests, and characteristics of patients diagnosed with primary aldosteronism.
Observational study of blood pressure control and cardiovascular risk in patients with endocrine forms of hypertension after targeted therapy. This research evaluates changes in blood pressure, medication requirements, and cardiovascular outcomes after adrenalectomy or specific medical treatment for endocrine hypertension.
Study of pheochromocytoma and paraganglioma presenting with hypertensive crises. The thesis describes clinical features, diagnostic delays, management of blood pressure during perioperative period, and long term follow up of blood pressure control.
Cross sectional analysis of thyroid dysfunction in patients with difficult to control hypertension. This project evaluates frequency of hyperthyroidism and hypothyroidism and their correlation with blood pressure patterns and cardiovascular risk in hypertensive patients.
Study of Cushing syndrome associated hypertension: severity, metabolic profile, and resolution after treatment. The research documents blood pressure levels, accompanying metabolic abnormalities, and degree of improvement in hypertension after successful treatment of Cushing syndrome.
Observational study of sleep apnoea and obesity as contributors to difficult to control hypertension in endocrine clinics. This thesis assesses risk and diagnosis of obstructive sleep apnoea and obesity in hypertensive patients and their interplay with endocrine abnormalities.
Study of patient awareness and referral patterns for suspected endocrine hypertension among primary care and cardiology physicians. The project uses questionnaires or referral data to assess recognition of red flag features and use of appropriate endocrine evaluations in hypertensive patients.
Cross sectional study of end organ damage in endocrine and non endocrine hypertension in a tertiary care hospital. This research compares prevalence of left ventricular hypertrophy, chronic kidney disease, and retinopathy in patients with endocrine versus essential hypertension.
Study of adherence to antihypertensive therapy and lifestyle advice in patients treated for endocrine and non endocrine hypertension. The thesis assesses medication adherence, lifestyle modifications, and their impact on blood pressure control and cardiovascular risk factors.

9. Endocrine Oncology including Thyroid, Adrenal, Pituitary and Neuroendocrine Tumours

Prospective observational study of differentiated thyroid carcinoma: presentation, risk stratification, and treatment outcomes. This thesis evaluates tumour characteristics, lymph node involvement, risk category, use of radioiodine ablation, thyroxine suppression, and recurrence or survival outcomes.
Study of medullary thyroid carcinoma: clinical features, genetic testing practices, and outcomes. The project analyses sporadic and hereditary cases, calcitonin and carcinoembryonic antigen levels, genetic screening where available, and long term follow up data.
Observational study of aggressive thyroid cancers including poorly differentiated and anaplastic carcinoma. This research describes clinical presentation, treatment approaches, palliation, and survival outcomes in patients with advanced thyroid malignancy.
Study of adrenal cortical carcinoma and metastatic adrenal lesions managed in an endocrinology and oncology collaboration. The thesis documents clinical presentation, hormonal excess, imaging findings, surgical resection, adjuvant therapy, and outcomes in adrenal malignancies.
Cross sectional analysis of pituitary tumours with aggressive behaviour or atypical features. This project evaluates growth patterns, invasiveness, high proliferation indices where available, treatment modalities, and recurrence in aggressive pituitary tumours.
Study of gastroenteropancreatic neuroendocrine tumours: hormonal syndromes, localisation, and treatment outcomes. The research describes functioning and non functioning neuroendocrine tumours, imaging modalities for localisation, and outcomes following surgery and medical therapy.
Observational study of multiple endocrine neoplasia syndromes: clinical spectrum, screening protocols, and family counselling. This thesis evaluates manifestations, timing of tumour detection, genetic testing where available, and cascade screening and counselling practices in affected families.
Study of quality of life and long term endocrine sequelae in survivors of endocrine cancers. The project assesses fatigue, mood, body image, and endocrine complications such as hypothyroidism, hypoparathyroidism, or adrenal insufficiency after cancer therapy.
Cross sectional analysis of diagnostic delays and referral patterns in patients with endocrine malignancies. This research evaluates time from symptom onset to specialist referral, contributing factors to delay, and opportunities for earlier diagnosis.
Study of patient knowledge and information needs regarding prognosis and follow up in endocrine cancer. The thesis uses interviews or questionnaires to explore understanding of disease stage, treatment goals, and expectations, and identifies information gaps in counselling.

10. Pediatric Endocrinology

Cross sectional study of short stature in children referred to a paediatric endocrinology clinic. This thesis evaluates causes such as familial short stature, constitutional delay, growth hormone deficiency, chronic diseases, and undernutrition, and documents auxological parameters and investigations.
Study of disorders of puberty: precocious and delayed puberty in boys and girls. The project analyses age at onset, clinical features, hormonal evaluation, imaging findings, underlying diagnoses, and treatment outcomes in children with pubertal disorders.
Observational study of type 1 diabetes mellitus in children and adolescents attending a paediatric endocrine clinic. This research documents glycaemic control, insulin regimens, acute complications, screening for chronic complications, and psychosocial challenges in paediatric type 1 diabetes.
Study of childhood obesity and its metabolic complications in school aged and adolescent children. The thesis evaluates body mass index, blood pressure, lipid profile, insulin resistance, and psychosocial impact in children with overweight and obesity.
Cross sectional analysis of congenital hypothyroidism: screening, timing of diagnosis, and neurodevelopmental outcomes. This project examines coverage and timeliness of newborn screening, treatment initiation, and early developmental milestones in children with congenital hypothyroidism.
Study of congenital adrenal hyperplasia: clinical profile, hormonal control, and growth outcomes in affected children. The research evaluates presentation, glucocorticoid and mineralocorticoid therapy, growth and pubertal development, and challenges in long term management.
Observational study of rickets and other metabolic bone diseases in children in an Indian or GCC tertiary hospital. This thesis documents nutritional and non nutritional rickets, biochemical profile, radiological features, and response to treatment.
Study of adrenal and gonadal disorders of sex development presenting to paediatric endocrinology services. The project analyses clinical features, hormonal evaluation, imaging, karyotyping where available, multidisciplinary management, and psychosocial aspects of disorders of sex development.
Cross sectional analysis of school performance, growth, and quality of life in children with chronic endocrine disorders. This research uses questionnaires and records to assess academic performance, absenteeism, growth parameters, and quality of life in children with conditions such as diabetes, hypothyroidism, and growth hormone deficiency.
Study of transition from paediatric to adult endocrinology services in adolescents with chronic endocrine disorders. The thesis evaluates readiness for transition, continuity of care, adherence to therapy, and early adult outcomes in young people moving from paediatric to adult endocrine clinics.
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