1. Cardiovascular Medicine

1. A prospective cohort study of ambulatory blood pressure variability and its association with left ventricular hypertrophy in hypertensive patients using 24-hour ABPM

2. A randomized controlled trial comparing high-intensity versus moderate-intensity statin therapy on plaque regression measured by carotid ultrasound in patients with coronary artery disease

3. A cross-sectional analysis of serum NT-proBNP and troponin I levels as predictors of adverse outcomes in acute decompensated heart failure

4. A retrospective cohort evaluation of adverse cardiovascular events in diabetic versus non-diabetic patients post–percutaneous coronary intervention

5. An in vitro assay of endothelial progenitor cell function under hyperglycemic versus normoglycemic conditions: implications for vascular repair

6. A case-control study of genetic polymorphisms in the renin–angiotensin system and their correlation with resistant hypertension

7. A methodological validation of automated ECG interpretation software versus cardiologist review for atrial fibrillation detection in primary care

8. A systematic review and meta-analysis of beta-blocker efficacy in reducing mortality after myocardial infarction: comparison across age strata

9. An in silico computational model of coronary flow reserve under varying degrees of stenosis to predict ischemic thresholds

10. A narrative review of novel anticoagulant reversal agents and their clinical application in internal medicine

2. Respiratory Medicine

1. A prospective observational study of serum eosinophil count and exhaled nitric oxide levels as predictors of exacerbation frequency in asthma

2. A randomized double-blind trial of inhaled tiotropium versus placebo as add-on therapy in poorly controlled chronic obstructive pulmonary disease

3. A cross-sectional evaluation of pulmonary function test pattern differences in smoking versus biomass fuel–exposed COPD patients

4. A retrospective cohort study of outcomes and complications in community-acquired pneumonia treated in hospital versus outpatient settings

5. An in vitro biofilm formation assay of nontuberculous mycobacteria isolates: antibiotic susceptibility profiling

6. A case-control investigation of IL-6 and CRP levels in pleural fluid for differentiation of malignant versus benign pleural effusions

7. A methodological validation of portable spirometry devices against laboratory-standard spirometers in field settings

8. A systematic review and meta-analysis of risk factors for pulmonary embolism in hospitalized medical patients

9. An in silico docking study of novel small molecules targeting the SARS-CoV-2 main protease

10. A narrative review of biologic therapies in severe eosinophilic asthma: mechanism of action and clinical outcomes

3. Gastroenterology & Hepatology

1. A prospective observational cohort study of transient elastography and serum fibrosis markers (APRI, FIB-4) in chronic hepatitis C patients pre- and post-antiviral therapy

2. A randomized controlled trial comparing proton pump inhibitor double-dose versus standard-dose in healing of high-risk peptic ulcers

3. A cross-sectional analysis of fecal calprotectin levels and endoscopic activity in inflammatory bowel disease patients in remission

4. A retrospective cohort evaluation of outcomes in cirrhotic patients with spontaneous bacterial peritonitis treated with albumin infusion versus standard care

5. An in vitro hepatocyte culture study assessing the cytotoxicity of novel herbal extracts used in traditional medicine

6. A case-control study of Helicobacter pylori virulence factor genotypes in patients with gastric cancer versus chronic gastritis

7. A methodological validation of wireless pH and motility capsule measurements versus conventional esophageal manometry

8. A systematic review and meta-analysis of corticosteroid efficacy in autoimmune hepatitis induction therapy

9. An in silico population pharmacokinetic model of oral tacrolimus in post-liver-transplant patients: dosage optimization

10. A narrative review of emerging non-invasive biomarkers for early detection of hepatocellular carcinoma

4. Endocrinology & Metabolism

1. A prospective randomized trial of continuous glucose monitoring–guided insulin therapy versus standard SMBG in type 1 diabetes: glycemic variability and hypoglycemia incidence

2. A cross-sectional study correlating vitamin D levels with insulin resistance markers in patients with metabolic syndrome

3. A retrospective cohort analysis of thyroid function test abnormalities and cardiovascular outcomes in subclinical hypothyroidism

4. An in vitro adipocyte differentiation assay evaluating novel PPARγ agonists for anti-diabetic potential

5. A case-control investigation of mitochondrial DNA variants in patients with familial combined hyperlipidemia versus controls

6. A methodological validation of point-of-care HbA1c devices against laboratory HPLC methods in primary care clinics

7. A systematic review and meta-analysis of GLP-1 receptor agonists versus SGLT2 inhibitors on weight loss and cardiovascular outcomes

8. An in silico predictive model of fracture risk in type 2 diabetic versus non-diabetic populations using clinical parameters

9. A pilot interventional study of intermittent fasting effects on hepatic insulin sensitivity and lipid profiles in prediabetic subjects

10. A narrative review of emerging cell-based therapies for type 1 diabetes: stem cells and islet transplantation

5. Nephrology & Fluid–Electrolyte Disorders

1. A prospective cohort study of urinary biomarkers (NGAL, KIM-1) for early detection of acute kidney injury in sepsis patients

2. A randomized controlled trial comparing balanced crystalloids versus normal saline for fluid resuscitation in critically ill patients: renal outcomes

3. A cross-sectional evaluation of serum and urine osmolality ratios in differentiating types of hyponatremia in hospitalized patients

4. A retrospective cohort analysis of outcomes in end-stage renal disease patients undergoing hemodialysis versus peritoneal dialysis

5. An in vitro assay of podocyte injury markers in cultured human glomerular cells exposed to high glucose concentrations

6. A case-control study of complement activation profiles in patients with atypical hemolytic uremic syndrome versus healthy controls

7. A methodological validation of handheld point-of-care creatinine measurement devices in rural clinics

8. A systematic review and meta-analysis of sodium bicarbonate therapy efficacy in prevention of contrast-induced nephropathy

9. An in silico pharmacodynamic model of diuretic response in heart failure patients with renal impairment

10. A narrative review of novel renal replacement therapies and wearable artificial kidneys

6. Rheumatology & Connective Tissue Disorders

1. A prospective cohort study of ultrasound-detected synovial inflammation and its correlation with DAS28 scores in rheumatoid arthritis

2. A randomized double-blind trial of methotrexate monotherapy versus combination with leflunomide in early rheumatoid arthritis: radiographic progression

3. A cross-sectional evaluation of HLA-B27 prevalence and clinical manifestations in patients with ankylosing spondylitis versus controls

4. A retrospective cohort analysis of biologic therapy discontinuation rates and predictors in psoriatic arthritis

5. An in vitro cartilage explant culture assay assessing the protective effects of novel MMP inhibitors

6. A case-control investigation of anti-dsDNA levels and complement consumption in systemic lupus erythematosus flares versus remission

7. A methodological validation of nailfold capillaroscopy scoring systems in systemic sclerosis clinics

8. A systematic review and meta-analysis of JAK inhibitors efficacy in ulcerative colitis: comparison with anti-TNF agents

9. An in silico network analysis of cytokine–chemokine interactions in Sjögren’s syndrome pathogenesis

10. A narrative review of emerging small-molecule therapies targeting intracellular signaling in autoimmune diseases

7. Infectious Diseases & Tropical Medicine

1. A prospective observational study of antimicrobial stewardship interventions on antibiotic prescribing and resistance patterns in a tertiary care hospital

2. A randomized controlled trial of artemisinin-based combination therapy versus quinine in severe malaria: parasite clearance and clinical outcomes

3. A cross-sectional seroprevalence study of dengue virus NS1 and IgM antibodies in a post-monsoon urban population

4. A retrospective cohort analysis of treatment outcomes and predictors in multi-drug resistant tuberculosis patients

5. An in vitro time-kill assay of novel antimicrobial peptides against ESBL-producing Enterobacteriaceae

6. A case-control study of plasma cytokine profiles in survivors versus non-survivors of septic shock

7. A methodological validation of GeneXpert MTB/RIF Ultra assay against culture in pediatric tuberculosis diagnosis

8. A systematic review and meta-analysis of prophylactic antibiotic regimens for prevention of spontaneous bacterial peritonitis in cirrhosis

9. An in silico docking study of novel small molecules targeting the HIV reverse transcriptase active site

10. A narrative review of vaccine development strategies for emerging zoonoses: barriers and opportunities

8. Hematology & Oncology

1. A prospective observational study of D-dimer trends and thrombotic event prediction in cancer-associated thrombosis

2. A randomized controlled trial comparing oral versus injectable iron therapy in iron-deficiency anemia: hemoglobin response and side effects

3. A cross-sectional analysis of bone marrow fibrosis grading and its correlation with peripheral blood parameters in myelofibrosis

4. A retrospective cohort evaluation of outcomes in acute promyelocytic leukemia treated with ATRA plus arsenic trioxide versus ATRA plus chemotherapy

5. An in vitro chemosensitivity assay of primary lymphoma cells to rituximab and novel antibody–drug conjugates

6. A case-control study of TP53 mutation prevalence in therapy-related versus de novo acute myeloid leukemia

7. A methodological validation of flow cytometry–based minimal residual disease detection versus PCR in pediatric ALL

8. A systematic review and meta-analysis of CAR-T cell therapy efficacy and toxicity in relapsed/refractory B-cell malignancies

9. An in silico prediction model of erythropoiesis-stimulating agent response in chemotherapy-induced anemia

10. A narrative review of novel small-molecule inhibitors targeting oncogenic pathways in solid tumors

9. Geriatric Medicine & Preventive Care

1. A prospective cohort study of comprehensive geriatric assessment indicators and their predictive value for one-year mortality in hospitalized elders

2. A randomized controlled trial of vitamin D and calcium supplementation versus placebo on fall incidence and bone density in nursing home residents

3. A cross-sectional survey of medication adherence and polypharmacy determinants in community-dwelling elderly with multimorbidity

4. A retrospective cohort analysis of pneumococcal and influenza vaccination status and hospitalization rates in geriatric patients

5. An in vitro assay of novel senolytic compounds on cultured human fibroblasts: markers of cellular senescence

6. A case-control evaluation of sarcopenia biomarkers (myostatin, IL-6) in frail versus non-frail older adults

7. A methodological validation of frailty screening tools (FRAIL scale, Clinical Frailty Scale) in primary care

8. A systematic review and meta-analysis of community-based interventions for prevention of cognitive decline in the elderly

9. An in silico population health model of aging demographics and impact of preventive strategies on healthcare utilization

10. A narrative review of novel geroprotective agents and their mechanisms in age-related diseases

10. Recent Advances in Internal Medicine

1. A scoping review of artificial intelligence applications in early disease detection and prognosis prediction in internal medicine

2. A prospective pilot study of telemedicine intervention impact on chronic disease management and patient satisfaction in rural clinics

3. A methodological assessment of wearable biosensors for continuous monitoring of vital signs and arrhythmia detection in at-risk populations

4. An in vitro validation of microfluidic chip platforms for rapid point-of-care multiplex biomarker analysis in emergency settings

5. An in silico systems biology integration of multi-omics data to identify biomarkers of sepsis severity and therapeutic targets

6. A systematic review of CRISPR-based diagnostic assays for rapid detection of pathogens and genetic disorders

7. A narrative review of blockchain technology applications for secure EHR management and data interoperability in healthcare

8. A pilot clinical trial of gut microbiome–modulating interventions (probiotics, fecal transplant) in metabolic syndrome patients

9. A retrospective data-mining analysis of electronic health record big data to predict hospital readmission risk in chronic disease cohorts

10. A narrative review of personalized medicine approaches integrating genomics, proteomics, and pharmacogenomics in internal medicine