1. Histopathology and Tumor Pathology

1. A retrospective cross-sectional study of immunohistochemical expression of p53, Ki-67, and Bcl-2 in breast carcinoma and correlation with histologic grade

2. A prospective cohort analysis of morphometric nuclear parameters in gastric adenocarcinoma for prediction of lymph node metastasis

3. An in vitro validation of dual-color fluorescence in situ hybridization (FISH) for HER2 gene amplification in gastric cancer biopsies

4. A comparative observational study of sentinel lymph node biopsy versus axillary dissection: histopathological assessment and morbidity outcomes

5. An in situ digital image analysis of microvessel density using CD34 immunostaining in colorectal carcinoma: prognostic implications

6. A retrospective cohort study of mismatch repair protein immunohistochemistry in endometrial carcinoma and correlation with MSI status

7. A case-control morphometric evaluation of nuclear area and shape in high-grade versus low-grade urothelial carcinoma

8. A randomized controlled laboratory comparison of manual versus automated immunostaining platforms for cytokeratin detection in lung biopsies

9. A systematic review and meta-analysis of tumor infiltrating lymphocytes (TILs) scoring methods in melanoma prognosis

10. A narrative review of WHO classification updates in hematolymphoid neoplasms and their diagnostic utility

2. Hematopathology and Coagulation Disorders

1. A prospective observational study of peripheral blood smear morphology and automated cell counter parameters in iron-deficiency versus thalassemia trait

2. A cross-sectional assay validation of flow cytometry–based minimal residual disease detection in acute lymphoblastic leukemia

3. A retrospective cohort analysis of bone marrow cellularity indices in aplastic anemia and their relation to clinical severity

4. An in vitro comparison of prothrombin time and thromboelastography for assessment of coagulation status in liver cirrhosis patients

5. A case-control evaluation of platelet function using light transmission aggregometry in inherited versus acquired thrombocytopathy

6. A methodological validation of next-generation sequencing panel for mutational profiling in myeloproliferative neoplasms

7. A randomized laboratory trial of anticoagulant efficacy: warfarin versus direct oral anticoagulants on vitamin K–dependent clotting factors

8. A systematic review of immunophenotypic markers in differentiating follicular lymphoma from reactive lymphoid hyperplasia

9. A retrospective data-mining study of coagulation factor VIII activity levels in hemophilia A severity classification

10. A narrative review of novel hemostatic agents and their pathological evaluation in bleeding disorders

3. Cytopathology and Effusion Analysis

1. A cross-sectional diagnostic accuracy study of liquid-based cytology versus conventional smear in cervical cancer screening

2. A prospective evaluation of cell block immunocytochemistry for differentiating reactive mesothelial cells from adenocarcinoma in pleural effusions

3. An in vitro comparative assessment of rapid onsite evaluation (ROSE) versus standard cytology in EUS-FNA samples of pancreatic masses

4. A retrospective cohort study of Bethesda System category distribution and malignancy rates in thyroid fine-needle aspiration cytology

5. An observational validation of automated image analysis software for quantification of atypical cells in urinary cytology

6. A case-control evaluation of liquid biopsy–derived cell-free DNA cytology for early detection of lung carcinoma

7. A methodological study on adequacy rates and diagnostic yields of ultrasound-guided pleural biopsy versus cytology in exudative effusions

8. A systematic review of dual-staining immunocytochemistry panels in effusion cytology for mesothelioma diagnosis

9. A retrospective analysis of cytomorphometric nuclear features in high-grade versus low-grade urothelial carcinoma from voided urine samples

10. A narrative review of emerging digital cytopathology and AI algorithms for automated specimen screening

4. Molecular Pathology and Genomic Biomarkers

1. A prospective cohort study of EGFR mutation detection using ARMS-PCR and NGS in non-small cell lung cancer patients and correlation with treatment response

2. A cross-sectional in silico and in vitro validation of BRCA1/2 pathogenic variants in ovarian carcinoma using droplet digital PCR

3. A retrospective analysis of BRAF V600E mutation frequency in colorectal carcinoma and its association with CpG island methylator phenotype

4. A methodological validation of microRNA expression profiling by qRT-PCR in gastric cancer tissue and blood samples

5. An in vitro functional study of ALK rearrangements: comparison of FISH, IHC, and RT-PCR detection accuracy in lung adenocarcinoma

6. A case-control investigation of circulating tumor DNA (ctDNA) methylation patterns as early biomarkers for hepatocellular carcinoma

7. A systematic review of tumor mutational burden assessment methods and their predictive value for immunotherapy across cancers

8. A randomized laboratory comparison of targeted panel versus whole-exome sequencing for mutation discovery in pediatric brain tumors

9. A narrative review of liquid biopsy applications in monitoring minimal residual disease in hematological malignancies

10. A meta-analysis of gene-expression signatures for prognostication in diffuse large B-cell lymphoma

5. Renal and Liver Pathology

1. A prospective observational study of histopathological classification and Oxford MEST-C score correlation with clinical outcome in IgA nephropathy

2. A retrospective cohort analysis of grading and staging criteria (METAVIR versus Ishak) in hepatitis C–related liver fibrosis and correlation with transient elastography

3. An in vitro immunofluorescence study of podocyte injury markers (nephrin, podocin) in diabetic nephropathy renal biopsies

4. A case-control morphometric assessment of bile duct proliferation and ductular reaction in alcoholic versus non-alcoholic steatohepatitis

5. A methodological validation of digital pathology for automated fibrosis quantification in liver biopsy specimens

6. A cross-sectional analysis of complement deposition patterns by immunohistochemistry in membranous nephropathy

7. A systematic review of histopathological scoring systems for non-alcoholic fatty liver disease and their clinical relevance

8. A retrospective study of electron microscopy findings in renal transplant biopsies with early versus late rejection

9. A pilot experimental evaluation of Sirius Red staining quantification for collagen assessment in chronic liver disease

10. A narrative review of emerging biomarkers in renal and hepatic tissue for precision pathology

6. Cardiovascular and Pulmonary Pathology

1. A retrospective observational study of histopathological features of ruptured versus stable atherosclerotic plaques in coronary arteries

2. A prospective cohort evaluation of immunohistochemical expression of smooth muscle actin and CD31 in pulmonary arterial hypertension lung specimens

3. An in vitro ultrastructural study of viral inclusion bodies in myocarditis cases using transmission electron microscopy

4. A case-control morphometric analysis of alveolar septal thickness in interstitial lung disease subtypes on surgical lung biopsies

5. A methodological validation of computerized planimetry for quantifying myocardial fibrosis in endomyocardial biopsy samples

6. A cross-sectional evaluation of CD68-positive macrophage density in acute versus chronic pulmonary embolism thrombi

7. A systematic review of histopathological criteria and survival outcomes in cardiac sarcoidosis

8. A retrospective cohort analysis of lymphocytic infiltration patterns in acute versus chronic myocarditis

9. A pilot study of polarized light microscopy for identifying birefringent crystals in crystal-induced arthropathy of cardiac valves

10. A narrative review of novel histological staining techniques for pulmonary fibrosis research

7. Neuropathology and Neurodegenerative Diseases

1. A cross-sectional immunohistochemical study of tau and β-amyloid deposition patterns in Alzheimer’s disease versus age-matched controls

2. A retrospective cohort analysis of α-synuclein and Lewy body distribution in Parkinson’s disease brain autopsies

3. An in situ hybridization assay validation for detecting prion protein gene expression in variant Creutzfeldt-Jakob disease

4. A case-control morphometric evaluation of neuronal loss in hippocampal subfields in temporal lobe epilepsy

5. A methodological validation of digital slide analysis for quantifying microglial activation markers in multiple sclerosis lesions

6. A prospective cohort study of phosphorylated TDP-43 immunoreactivity in amyotrophic lateral sclerosis postmortem tissue

7. A systematic review of histopathological staging criteria in frontotemporal lobar degeneration and correlation with clinical subtypes

8. A retrospective experimental study of inclusion body myositis versus polymyositis muscle biopsy features using electron microscopy

9. A narrative review of emerging single-cell transcriptomics applications in neuropathology research

10. A pilot immunofluorescence study of synaptic protein alterations in autism spectrum disorder postmortem brain samples

8. Pediatric and Developmental Pathology

1. A prospective observational study of congenital diaphragmatic hernia specimen histology and correlation with neonatal respiratory outcomes

2. A cross-sectional evaluation of placental pathology features in preterm versus term intrauterine growth restriction cases

3. An in vitro immunohistochemical analysis of apoptosis markers (caspase-3, Bcl-2) in pediatric acute lymphoblastic leukemia bone marrow samples

4. A retrospective cohort analysis of necrotizing enterocolitis intestinal biopsy findings in surgical versus nonsurgical management

5. A case-control evaluation of neuronal migration disorder histopathology in cortical dysplasia versus controls

6. A methodological validation of placental volumetry using 3D ultrasound correlated with histopathological villous maturation

7. A systematic review of pathological correlates of sudden infant death syndrome: autopsy findings and risk factors

8. A retrospective data-mining study of pediatric renal tumor histologic subtypes and survival outcomes

9. A pilot immunohistochemical study of VEGF and CD34 expression in infantile hemangioma tissue samples

10. A narrative review of developmental pathology of congenital heart defects and evolving diagnostic criteria

9. Infectious Disease and Inflammatory Pathology

1. A cross-sectional histopathological and immunohistochemical study of granuloma architecture in pulmonary tuberculosis versus sarcoidosis

2. A prospective cohort evaluation of viral cytopathic effect patterns in HSV, CMV, and adenovirus infections in transplant biopsy specimens

3. An in vitro detection and quantification of fungal elements in mucormycosis using special stains versus PCR assays

4. A retrospective cohort analysis of placental pathology in malaria-infected versus uninfected pregnant women

5. A case-control immunohistochemical study of PD-L1 expression in chronic hepatitis B versus hepatitis C liver biopsies

6. A methodological validation of multiplex immunofluorescence for simultaneous detection of multiple pathogens in tissue sections

7. A systematic review of histopathological markers for predicting severity in dengue hemorrhagic fever autopsy studies

8. A retrospective data-mining study of immune cell infiltrate patterns in lupus nephritis classes and clinical outcomes

9. A pilot electron microscopy study of bacterial ultrastructure in necrotizing fasciitis tissue specimens

10. A narrative review of emerging immunopathology insights in COVID-19 lung injury

10. Recent Advances in Pathology

1. A scoping review of artificial intelligence algorithms for automated histopathological image diagnosis in cancer

2. An in vitro validation of multiplexed digital spatial profiling for simultaneous analysis of protein and RNA in FFPE tissue

3. A prospective observational study of nanoparticle-based contrast agents for enhanced MR-guided biopsy and subsequent histopathology correlation

4. A methodological assessment of liquid biopsy–derived exosomal proteins as surrogate markers for tissue pathology

5. An in silico network analysis of multi-omics data integration in precision oncology pathology

6. A pilot trial of Raman spectroscopy–guided intraoperative margin assessment in brain tumor surgery

7. A systematic review of spatial transcriptomics applications in tumor microenvironment research

8. An experimental study of 3D bioprinted tissue models for high-throughput pathological drug screening

9. A retrospective data-mining analysis of digital pathology archives using machine learning for biomarker discovery

10. A narrative review of CRISPR-based diagnostics and therapeutic monitoring in pathological conditions