1. Pharmacokinetics and Drug Metabolism

1. A prospective crossover bioequivalence study of immediate-release versus extended-release formulation of metoprolol in healthy volunteers using LC-MS/MS

2. An in vitro human liver microsome assay to characterize CYP3A4 and CYP2D6–mediated metabolism of a novel antidiabetic compound

3. A population pharmacokinetic modeling study of vancomycin in critically ill Indian ICU patients using NONMEM

4. A randomized parallel-group trial comparing pharmacokinetic profiles of ibuprofen in fed versus fasting states

5. A retrospective cohort analysis of drug–drug interaction effects on tacrolimus trough levels in renal transplant recipients

6. An in vitro assessment of P-glycoprotein efflux inhibition on paclitaxel uptake in Caco-2 cell monolayers

7. A case-control study of genetic polymorphisms in CYP2C19 and clopidogrel active metabolite concentrations in acute coronary syndrome patients

8. A methodological validation of dried blood spot sampling for quantification of antiepileptic drug levels by UPLC-MS/MS

9. An in silico physiologically based pharmacokinetic (PBPK) modeling of a novel monoclonal antibody in pediatric populations

10. A systematic review and meta-analysis of absorption variability factors in subcutaneous versus intramuscular depot antipsychotic formulations

2. Pharmacodynamics and Mechanisms of Action

1. An in vitro receptor-binding assay study to determine the Ki values of new benzodiazepine analogs at GABAA receptor subtypes

2. A prospective observational evaluation of platelet aggregation inhibition by different P2Y12 inhibitors using light transmission aggregometry in ACS patients

3. A randomized controlled laboratory study of L-type calcium channel blocker potency in isolated rat aortic ring preparations

4. A mechanistic in vitro study of NF-κB pathway modulation by curcumin in LPS-stimulated macrophages

5. A case-control clinical assessment of β-adrenergic receptor sensitivity in asthmatic versus non-asthmatic subjects via bronchoprovocation testing

6. An in vitro enzyme inhibition kinetics study of COX-2 selectivity for novel NSAID derivatives

7. A retrospective analysis of dose–response relationships for levodopa–carbidopa in Parkinson’s disease patients and motor symptom improvement

8. A methodological validation of fluorescence resonance energy transfer (FRET) assay for GPCR internalization studies

9. An in silico molecular docking and MD simulation to predict binding interactions of selective serotonin reuptake inhibitors with SERT

10. A systematic review of molecular mechanisms underlying chemotherapy-induced cardiotoxicity and potential protective agents

3. Clinical Pharmacology and Therapeutic Drug Monitoring

1. A prospective observational study of daily versus twice-daily tacrolimus therapeutic drug monitoring in liver transplant recipients

2. A cross-sectional survey of antibiotic prescribing patterns and adherence to hospital antibiotic stewardship guidelines in tertiary care

3. A randomized open-label trial of weight-based versus fixed-dose vancomycin dosing protocols in septic patients with MRSA

4. A case-control evaluation of linezolid trough concentrations and hematological toxicity in critically ill versus non-critically ill patients

5. A retrospective cohort study correlating phenytoin serum levels with seizure control and adverse events in pediatric patients

6. A methodological validation of immunoassay versus LC-MS/MS for polymyxin B concentration measurement in serum

7. A systematic review of therapeutic drug monitoring practices for narrow therapeutic index drugs in India

8. An in vitro stability study of amikacin and gentamicin in plasma stored at various temperatures and durations

9. A cross-sectional study of patient and physician perspectives on pharmacogenetic-guided warfarin dosing

10. A narrative review of novel biomarkers for optimizing therapeutic drug monitoring in oncology

4. Toxicology and Safety Pharmacology

1. An in vivo LD50 determination and safety margin calculation for a new synthetic opioid in rodent models

2. An in vitro hepatotoxicity assessment of herbal supplement extracts using primary human hepatocyte cultures and ALT/AST release assays

3. A retrospective analysis of adverse drug reaction reports for anti-tubercular therapy in a tertiary care pharmacovigilance database

4. A randomized controlled animal study of cardiotoxicity biomarkers (troponin I, CK-MB) following doxorubicin administration in rats

5. A case-control postmortem toxicological evaluation of opioid and benzodiazepine levels in suspected drug overdose deaths

6. An in vitro genotoxicity study of cosmetic ingredient candidates using Ames test and micronucleus assay

7. A systematic review and meta-analysis of organophosphate pesticide poisoning outcomes and best supportive care protocols

8. A methodological validation of direct infusion mass spectrometry for rapid toxicant screening in emergency settings

9. An in silico predictive toxicology study using QSAR models to assess cardiotoxic potential of novel small molecules

10. A narrative review of emerging biomarkers for early detection of drug-induced liver injury

5. Neuropharmacology and Behavioral Studies

1. A prospective double-blind randomized trial of low-dose ketamine infusion versus placebo for treatment-resistant depression assessing HAM-D scores

2. An in vivo microdialysis study of extracellular dopamine levels in striatum following administration of novel psychostimulant analogs in rodent models

3. A cross-sectional clinical evaluation of cognitive function using CANTAB battery in Alzheimer’s patients on cholinesterase inhibitors

4. A case-control behavioral assessment of anxiolytic effects of a standardized valerian extract versus diazepam in elevated plus maze test in mice

5. A retrospective cohort study of antipsychotic-induced extrapyramidal symptom incidence in first-episode schizophrenia patients

6. An in vitro electrophysiological patch-clamp study of NMDA receptor antagonists on rat hippocampal neurons

7. A methodological validation of open-field test automation using video-tracking software for rodent locomotor studies

8. An in silico pharmacophore modeling of dopamine D2 receptor ligands for antipsychotic drug discovery

9. A systematic review of pharmacological interventions for opioid use disorder and relapse prevention strategies

10. A narrative review of endocannabinoid system modulators in the management of chronic pain

6. Cardiovascular Pharmacology

1. A randomized controlled trial comparing efficacy and safety of high-intensity rosuvastatin versus atorvastatin in post-PCI patients: lipid profile changes and inflammatory markers

2. An in vitro vascular ring assay study to assess vasodilatory effects of a novel nitric oxide donor compound on rat aorta

3. A prospective observational study of QTc interval changes with different antiarrhythmic drug classes in hospitalized patients

4. A case-control evaluation of beta-blocker plasma levels and exercise capacity in heart failure patients classified by NYHA class

5. A retrospective cohort analysis of ACE inhibitor–associated angioedema incidence and risk factors in Indian hypertensive population

6. A methodological validation of platelet function analyzer versus light transmission aggregometry for assessment of antiplatelet therapy efficacy

7. A systematic review of pharmacologic management strategies for pulmonary arterial hypertension: efficacy and safety data

8. An in silico docking study of novel renin inhibitors and comparison with aliskiren in terms of binding affinity

9. An animal model study of myocardial ischemia–reperfusion injury mitigation by an experimental cardioprotective agent: troponin and infarct size assessment

10. A narrative review of challenges and advances in nanoparticle-based drug delivery for cardiovascular diseases

7. Oncology Pharmacology and Targeted Therapies

1. A prospective phase II clinical trial of single-agent PD-1 inhibitor in advanced melanoma: response rates and immune-related adverse events

2. An in vitro cytotoxicity and apoptosis induction study of a novel tyrosine kinase inhibitor on HER2-positive breast cancer cell lines

3. A case-control pharmacogenetic study of TPMT polymorphisms and 6-mercaptopurine tolerance in acute lymphoblastic leukemia patients

4. A retrospective cohort analysis of dose intensity and outcome correlations in platinum-based chemotherapy for ovarian cancer

5. A methodological validation of targeted LC-MS/MS assay for quantification of small-molecule inhibitors in patient plasma

6. An in silico ADMET prediction and lead optimization of new BCL-2 family inhibitors

7. A systematic review of drug repurposing strategies for rare cancers: clinical trial outcomes and research gaps

8. An animal xenograft study evaluating tumor growth inhibition by combination therapy of PARP inhibitor and radiotherapy

9. A randomized controlled trial of oral versus intravenous administration of a targeted agent in metastatic colorectal cancer: pharmacokinetics and patient-reported outcomes

10. A narrative review of CAR-T cell therapy pharmacology and cytokine release syndrome management

8. Anti-infective Pharmacology and Antimicrobial Stewardship

1. A prospective interventional study of antibiotic de-escalation protocols based on procalcitonin-guided algorithms in sepsis management

2. An in vitro checkerboard assay to evaluate synergistic antimicrobial activity of colistin and carbapenem combinations against MDR Gram-negative isolates

3. A cross-sectional audit of antifungal prescribing practices and adherence to national guidelines in hematology-oncology units

4. A randomized controlled trial of single-dose versus multidose azithromycin in community-acquired pneumonia: microbiological eradication and GI adverse events

5. A retrospective cohort evaluation of antiretroviral therapy adherence and virologic suppression rates in HIV-infected cohorts

6. A methodological validation of rapid PCR-based detection of MRSA colonization in surgical wards

7. A systematic review of stewardship interventions to reduce inappropriate broad-spectrum antibiotic use in critical care

8. An in silico docking study of novel neuraminidase inhibitors against emerging influenza virus strains

9. An in vitro time-kill synergy study of echinocandin and polyene combinations against Candida auris biofilms

10. A narrative review of challenges in development of new antibiotics for Gram-negative ‘superbugs’

9. Herbal and Traditional Medicines Pharmacology

1. A randomized double-blind placebo-controlled clinical trial of standardized Withania somnifera extract in generalized anxiety disorder: HAM-A score assessment

2. An in vitro antioxidant and cytoprotective assay of polyphenolic compounds from Ocimum sanctum on human hepatocyte cell lines

3. A prospective pilot study of ginger extract effects on chemotherapy-induced nausea and vomiting in cancer patients: VAS and RINVR scale

4. A cross-sectional phytochemical profiling and HPTLC method validation for detection of active alkaloids in Tinospora cordifolia

5. A case-control evaluation of herb–drug interactions between curcumin supplements and warfarin therapy: INR variability analysis

6. A methodological study of nanoformulation development for improved oral bioavailability of poorly soluble plant-derived compounds

7. A systematic review of clinical efficacy and safety of Ayurvedic formulations in management of rheumatoid arthritis

8. An in silico network pharmacology analysis of multi-component herbal mixtures used in traditional Chinese medicine for diabetes

9. An animal model study of hepatoprotective effects of silymarin in CCl4-induced liver injury in rats: histopathology and biochemical markers

10. A narrative review of regulatory challenges and quality control standards for herbal medicinal products

10. Recent Advances in Pharmacology

1. A scoping review of nanocarrier-based drug delivery systems: clinical translation and challenges in targeted therapy

2. An in vitro evaluation of CRISPR-Cas9–mediated gene editing for enzyme-targeted prodrug activation strategies

3. A prospective observational pilot of AI-driven dosing algorithms for insulin pump therapy in type 1 diabetes patients

4. A methodological assessment of organ-on-a-chip models for preclinical pharmacokinetic and toxicity screening

5. An in silico multi-omics integration study to predict adverse drug reactions using machine learning approaches

6. A randomized controlled trial of personalized pharmacogenomic-guided anticoagulant dosing versus standard care

7. A systematic review of antibody–drug conjugate pharmacology and clinical efficacy in hematologic malignancies

8. An experimental study of 3D bioprinted liver tissue for high-throughput drug metabolism and toxicity assays

9. A retrospective data-mining analysis of real-world evidence on off-label drug use in pediatric populations

10. A narrative review of ethical and regulatory considerations in first-in-human pharmacology trials