Nephrology Thesis Topics

Nephrology Thesis Topics

Nephrology focuses on the evaluation and management of acute and chronic kidney disorders, dialysis therapy, renal transplantation and complex electrolyte and acid–base abnormalities. This page provides 100 detailed, practical and clinically feasible Nephrology thesis topics suitable for DM Nephrology residents in India and trainees in Gulf Cooperation Council countries (UAE, Qatar, Oman, Kuwait, Bahrain, Saudi Arabia), including Arab Board Nephrology and Saudi Commission fellowship candidates.

The topics are search-optimised for Nephrology thesis topics, DM Nephrology dissertation topics India, GCC Nephrology research ideas, Arab Board kidney disease projects, dialysis research titles and transplant nephrology thesis topics. Most titles are structured as comparative clinical studies, observational cohorts and cross sectional analyses, ensuring feasibility across Indian and GCC nephrology units.

1. Acute Kidney Injury and Critical Care Nephrology

Comparative study of Kidney Disease Improving Global Outcomes versus RIFLE criteria for early detection of acute kidney injury in critically ill adults. This research evaluates diagnostic accuracy, timing of recognition and impact on intensive care unit mortality.
Comparative study of sepsis-associated acute kidney injury versus non-septic acute kidney injury in terms of progression to renal replacement therapy. The study assesses inflammatory markers, haemodynamic instability and early predictors of poor outcome.
Observational study of nephrotoxic drug exposure and incidence of acute kidney injury in medical and surgical ICU patients. This project identifies high-risk drug combinations and proposes a nephrotoxic stewardship model.
Comparative study of continuous renal replacement therapy versus sustained low-efficiency dialysis for haemodynamically unstable acute kidney injury patients. The thesis evaluates circuit life, fluid balance, metabolic control and survival outcomes.
Cross sectional analysis of community-acquired versus hospital-acquired acute kidney injury in a tertiary centre. This study reviews aetiology, comorbidities, delays in presentation and short-term renal recovery.
Observational study of biomarkers such as neutrophil gelatinase-associated lipocalin and cystatin C in predicting severity of acute kidney injury. The project evaluates correlation with renal replacement therapy requirement and length of hospital stay.
Comparative study of fluid-restrictive versus liberal fluid administration strategies in acute kidney injury patients with respiratory failure. This research assesses oxygenation index, ventilatory days and kidney recovery.
Observational study of rhabdomyolysis-associated acute kidney injury in trauma and non-trauma scenarios. The thesis evaluates predictors of dialysis need and electrolyte abnormalities.
Cross sectional analysis of acute kidney injury in obstetric critical care: incidence, causes and maternal outcomes. The project focuses on hypertensive disorders, haemorrhage and sepsis.
Comparative study of early versus delayed initiation of renal replacement therapy in severe acute kidney injury following sepsis or shock. This research analyses mortality, renal recovery and resource utilisation.

2. Chronic Kidney Disease and Progression Predictors

Cross sectional study of risk factors for chronic kidney disease in patients attending nephrology outpatient clinics in India and GCC regions. The project examines hypertension, diabetes, obesity, analgesic use and family history.
Comparative study of glycaemic control levels and progression of diabetic kidney disease in patients with moderate chronic kidney disease. This thesis tracks albuminuria trends, estimated glomerular filtration rate decline and retinopathy burden.
Observational study of role of proteinuria reduction as a predictor of renal survival in chronic kidney disease stages three and four. The research evaluates treatment responses to renin–angiotensin system blockers.
Comparative study of low-protein diet versus conventional diet on metabolic parameters and progression of chronic kidney disease. This project assesses adherence, nutritional status and biochemical markers.
Cross sectional analysis of mineral and bone disorder parameters in chronic kidney disease across different stages. The thesis examines calcium, phosphate, parathyroid hormone and vitamin D patterns.
Observational study of anaemia management in chronic kidney disease and association with quality of life. This research evaluates iron indices, erythropoietin dosing and fatigue severity.
Comparative study of sodium–glucose cotransporter-2 inhibitor therapy versus standard therapy alone in early diabetic kidney disease. The project examines albuminuria regression and preservation of renal function.
Cross sectional study of health literacy and awareness of chronic kidney disease in at-risk primary care populations. The thesis evaluates knowledge gaps, screening patterns and missed opportunities.
Observational study of hyperkalaemia episodes and associated medication changes in nondialysis chronic kidney disease patients. This research assesses prognostic significance and hospitalisation rates.
Comparative study of bicarbonate supplementation strategies on progression of metabolic acidosis and chronic kidney disease decline. The project tracks serum bicarbonate levels, muscle mass and estimated glomerular filtration rate slopes.

3. Hemodialysis Outcomes and Complications

Comparative study of arteriovenous fistula versus central venous catheter as vascular access for hemodialysis and their impact on infection and mortality. This project evaluates hospitalization patterns and long-term access survival.
Observational study of intradialytic hypotension: risk factors, frequency and management strategies. This research examines fluid removal rates, dialysate temperature and medication impact.
Comparative study of high-flux versus low-flux dialyzers on adequacy of dialysis and inflammation markers. The thesis assesses Kt/V, beta-2 microglobulin levels and quality of life.
Cross sectional analysis of anemia prevalence and management in chronic hemodialysis patients in India and GCC countries. This project evaluates iron status, erythropoiesis-stimulating agent doses and transfusion needs.
Observational study of vascular access complications including stenosis, thrombosis and pseudoaneurysm formation. The thesis identifies modifiable risk factors and ultrasonography features.
Comparative study of twice-weekly versus thrice-weekly hemodialysis regimens on residual renal function preservation. This research measures urine output, solute clearance and patient-reported outcomes.
Cross sectional analysis of dialysis-related pruritus and its association with laboratory parameters and quality of life. The study assesses calcium phosphate balance, inflammation and sleep disturbance.
Observational study of interdialytic weight gain patterns and dietary sodium adherence in maintenance hemodialysis patients. The project correlates fluid compliance with cardiovascular outcomes.
Comparative study of online hemodiafiltration versus high-flux hemodialysis on cardiovascular markers and hospitalization. This thesis evaluates left ventricular mass index and inflammatory markers.
Observational study of hepatitis B and hepatitis C prevalence in long-term hemodialysis patients. The project reviews vaccination rates, infection control lapses and seroconversion.

4. Peritoneal Dialysis Outcomes and Complications

Comparative study of continuous ambulatory peritoneal dialysis versus automated peritoneal dialysis on metabolic control and hospitalisation. This thesis assesses ultrafiltration, peritonitis rates and patient lifestyle preferences.
Observational study of peritonitis in peritoneal dialysis: microbial pattern, antibiotic response and technique survival. The research evaluates catheter-related complications and relapse.
Comparative study of straight versus coiled peritoneal dialysis catheters on inflow and outflow efficiency and infection risk. The project analyses surgical insertion techniques and mechanical complications.
Cross sectional analysis of adequacy of dialysis in peritoneal dialysis patients using weekly Kt/V and creatinine clearance measures. This study evaluates nutritional status and biochemical control.
Observational study of fluid prescription practices and volume overload in peritoneal dialysis patients. The project assesses sodium balance, residual renal function and blood pressure control.
Comparative study of icodextrin versus glucose-based dialysis solutions on ultrafiltration efficiency. This thesis evaluates patient tolerance and long-term peritoneal membrane effects.
Cross sectional analysis of abdominal wall hernias in peritoneal dialysis patients and associated risk factors. The research examines body mass index, intra-abdominal pressure and catheter site details.
Observational study of quality of life and caregiver burden in peritoneal dialysis households. This project evaluates independence, training adequacy and complications.
Comparative study of early versus late peritoneal dialysis catheter use after insertion and associated complications. The thesis examines leak rates, infection rates and technique failure.
Cross sectional analysis of peritoneal equilibration test results and predictors of fast transport status. This research examines implications for prescription adjustment.

5. Kidney Transplantation, Immunology and Outcomes

Comparative study of basiliximab versus anti-thymocyte globulin induction therapy in moderate-risk kidney transplant recipients. This thesis analyses acute rejection rates, infection risk and graft function.
Observational study of delayed graft function and associated risk factors in deceased donor kidney transplantation. The project evaluates donor characteristics, ischemia time and immunological matching.
Comparative study of tacrolimus-based versus cyclosporine-based maintenance immunosuppression on cardiovascular and metabolic outcomes. This research reviews nephrotoxicity, diabetes risk and long-term graft survival.
Cross sectional analysis of post-transplant infections including cytomegalovirus, BK virus and fungal infections. The thesis identifies timing, diagnostic strategies and outcomes.
Observational study of donor-specific antibodies and chronic antibody-mediated rejection on long-term graft function. This project correlates biopsy findings with immunological profiles.
Comparative study of steroid-free versus conventional steroid-based immunosuppression protocols. The research evaluates metabolic outcomes, rejection rates and quality of life.
Cross sectional analysis of frailty and nutritional status in kidney transplant recipients. The thesis examines association with hospitalization and graft survival.
Observational study of pregnancy outcomes in female kidney transplant recipients. This project reviews graft function, hypertension and neonatal outcomes.
Comparative study of living related versus living unrelated kidney transplantation on graft survival and rejection. The study evaluates immunological risk and socioeconomic factors.
Observational study of adherence to immunosuppressive medications using pharmacy refill patterns and clinical interviews. This project identifies predictors of nonadherence and associated graft dysfunction.

6. Glomerular Diseases and Renal Biopsy Correlations

Cross sectional study of immunoglobulin A nephropathy biopsy patterns and correlation with clinical severity at presentation. The project examines proteinuria levels, hypertension and renal dysfunction.
Comparative study of corticosteroid monotherapy versus combined immunosuppression in primary nephrotic syndrome in adults. The thesis evaluates remission rates, relapses and adverse effects.
Observational study of biopsy-proven lupus nephritis and its clinical–laboratory correlations. This research reviews pathological class, complement levels and treatment responses.
Comparative study of cyclophosphamide versus mycophenolate mofetil induction therapy in proliferative lupus nephritis. The project assesses renal remission, flares and toxicity.
Cross sectional analysis of membranous nephropathy with phospholipase A2 receptor antibody positivity and associated clinical outcomes. This thesis reviews proteinuria resolution and treatment responses.
Observational study of acute interstitial nephritis: etiological profile, biopsy findings and therapeutic outcomes. The project evaluates drug-induced causes, hypersensitivity patterns and steroid response.
Comparative study of minimal change disease versus focal segmental glomerulosclerosis in adults with nephrotic syndrome. The research examines steroid responsiveness, relapse and need for second-line therapy.
Cross sectional analysis of rapidly progressive glomerulonephritis and vasculitic disorders presenting with renal failure. The study reviews serology, biopsy features and short-term renal recovery.
Observational study of infection-related glomerulonephritis in children and adults. The project evaluates complement patterns, biopsy characteristics and prognosis.
Comparative study of renal biopsy complications in inpatient versus outpatient biopsy settings. This thesis evaluates bleeding risks, imaging follow-up and safety.

7. Hypertension and Renovascular Disorders

Cross sectional study of secondary hypertension prevalence in patients referred to a nephrology clinic. The thesis assesses renal parenchymal disease, endocrine causes and renovascular abnormalities.
Comparative study of ambulatory blood pressure monitoring versus clinic blood pressure in detection of masked and white-coat hypertension. This research examines risk factors, left ventricular mass and renal outcomes.
Observational study of resistant hypertension and associated comorbidities. The project evaluates medication adherence, aldosterone excess and renal artery stenosis.
Comparative study of different antihypertensive combinations on proteinuria reduction in chronic kidney disease. This thesis compares renin–angiotensin system blockers with calcium channel blockers and diuretics.
Cross sectional analysis of renovascular hypertension diagnosed by Doppler ultrasonography and computed tomography angiography. The study evaluates risk factors, stenosis severity and treatment plans.
Observational study of hypertensive emergencies presenting with acute kidney injury. This research examines neurological, cardiac and renal complications.
Comparative study of lifestyle-modification counselling versus standard care on blood pressure control in early chronic kidney disease. The project examines dietary adherence, weight loss and sodium intake.
Cross sectional analysis of pregnancy-related hypertension and its impact on postpartum renal function. The thesis explores pre-eclampsia, acute kidney injury and long-term estimated glomerular filtration rate decline.
Observational study of hypertensive nephrosclerosis and correlation of imaging findings with renal function. This project evaluates cortical thickness, echogenicity and disease progression.
Comparative study of fixed-dose combination therapies versus multi-pill regimens for hypertension management in chronic kidney disease. The research assesses adherence and blood pressure control.

8. Pediatric Nephrology

Cross sectional study of congenital anomalies of kidney and urinary tract in pediatric nephrology referrals. The project evaluates presentations, imaging findings and early renal outcomes.
Comparative study of steroid-sensitive versus steroid-resistant nephrotic syndrome in children. The thesis assesses relapse patterns, complications and treatment strategies.
Observational study of acute kidney injury in hospitalized children: incidence, causes and outcomes. This research reviews infections, dehydration, hemolysis and nephrotoxins.
Comparative study of intravenous versus oral cyclophosphamide in pediatric nephrotic syndrome. The project evaluates remission, toxicity and long-term outcomes.
Cross sectional analysis of urinary tract infection patterns in children and their antimicrobial susceptibility. The study examines recurrence and imaging abnormalities.
Observational study of growth and developmental delay in children with chronic kidney disease. The thesis evaluates nutritional factors, anemia and metabolic acidosis.
Comparative study of neurocognitive outcomes in children with chronic kidney disease versus healthy controls. This research evaluates memory, attention and school performance.
Cross sectional analysis of hypertension in children with chronic kidney disease and its impact on cardiac structure. The project uses echocardiography for assessing left ventricular hypertrophy.
Observational study of vesicoureteral reflux and follow-up renal scarring in pediatric patients. The thesis assesses imaging intervals and predictors of scarring.
Comparative study of continuous ambulatory peritoneal dialysis versus hemodialysis in pediatric end-stage kidney disease. This research evaluates quality of life, growth parameters and hospitalization.

9. Electrolyte Disorders and Acid–Base Imbalance

Cross sectional study of causes and clinical outcomes of hyponatremia in hospitalized adults. The thesis examines syndrome of inappropriate secretion of antidiuretic hormone, diuretics and heart failure contributions.
Comparative study of rapid versus slow correction protocols for symptomatic hyponatremia. This research evaluates neurological recovery and overcorrection complications.
Observational study of hyperkalemia episodes in chronic kidney disease and their association with medication exposure. The project reviews renin–angiotensin system blockers and potassium binders.
Comparative study of sodium bicarbonate therapy versus standard management in metabolic acidosis of chronic kidney disease. This thesis evaluates muscle mass, hospitalization and renal progression.
Cross sectional analysis of mixed acid–base disorders in critically ill patients. The study evaluates arterial blood gases and outcome correlations.
Observational study of hypomagnesemia prevalence and its association with arrhythmias in chronic kidney disease. The project examines dietary factors and drug-induced causes.
Comparative study of potassium-restricted diet versus unrestricted diet with binder therapy in chronic hyperkalemia. This research evaluates adherence, serum potassium trends and quality of life.
Cross sectional study of metabolic alkalosis in intensive care units and its impact on weaning from ventilation. The thesis evaluates diuretic use, electrolytes and respiratory drive.
Observational study of hypocalcemia in chronic kidney disease and association with parathyroid hormone levels. This project examines bone mineral disorder profiles and symptoms.
Comparative study of normal saline versus balanced crystalloid solutions on acid–base outcomes in hospitalized patients. The research evaluates hyperchloremic acidosis incidence and renal effects.

10. Nephrology Quality of Care, Outcomes and Epidemiology

Cross sectional analysis of chronic kidney disease awareness levels among high-risk populations in India and GCC regions. This thesis evaluates screening gaps and late presentation.
Observational study of hospital readmissions among dialysis patients and contributing factors. The project examines fluid overload, anemia, vascular access issues and infections.
Comparative study of integrated care clinics versus standard nephrology follow-up on chronic kidney disease progression. This research evaluates multidisciplinary involvement, dietary adherence and blood pressure control.
Cross sectional analysis of medication adherence patterns in chronic kidney disease and transplant patients. The study examines socioeconomic and psychological determinants.
Observational study of costs and economic burden associated with dialysis in public and private centres. This project evaluates out-of-pocket expenditure and catastrophic health impacts.
Comparative study of patient satisfaction and outcome markers in tele-nephrology versus in-person consultations. This research assesses feasibility for remote regions in India and Gulf countries.
Cross sectional analysis of end-stage kidney disease causes and trends over the last decade. The thesis examines diabetes, hypertension, glomerular diseases and unknown causes.
Observational study of palliative care needs among advanced chronic kidney disease patients not opting for dialysis. The project evaluates symptom burden and end-of-life care.
Comparative study of patient-reported quality of life in dialysis versus transplant recipients. This research uses standardized quality-of-life tools.
Cross sectional study of nephrology referral delays among diabetic patients and impact on renal outcomes. The thesis assesses primary care screening gaps and early intervention benefits.
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