Hematology Thesis Topics

Hematology Thesis Topics

Hematology is a core superspeciality that covers red cell disorders, white cell disorders, platelet and coagulation disorders, acute and chronic leukemias, lymphomas, multiple myeloma, bone marrow failure, transfusion medicine, and stem cell transplantation. This page presents a structured and search engine optimised list of one hundred practical and clinically relevant hematology thesis topics tailored for Doctorate of Medicine and equivalent superspeciality trainees in India. The topics are designed as comparative, cross sectional, and observational studies that can be feasibly completed in Indian tertiary care centres with adequate patient load, diagnostic facilities, and follow up, while retaining strong academic and publication potential.

1. Red Cell Disorders including Anaemias, Hemoglobinopathies, and Hemolytic Disorders

Comparative study of iron deficiency anaemia and anaemia of chronic disease in adult medical inpatients. This study compares clinical profile, iron studies, inflammatory markers, and bone marrow findings in patients with iron deficiency anaemia and anaemia of chronic disease and evaluates the diagnostic value of various indices in differentiating these two conditions.
Cross sectional study of vitamin B12 and folate deficiency anaemia in a tertiary care hospital. The project evaluates dietary habits, clinical features, peripheral smear patterns, serum vitamin levels, and neurological manifestations, and examines delays in diagnosis and treatment in patients with megaloblastic anaemia.
Observational study of red cell distribution width and its association with severity and aetiology of anaemia. This thesis analyses how red cell distribution width varies across iron deficiency, megaloblastic, haemolytic, and anaemia of chronic disease and assesses its usefulness as a simple screening parameter in routine reports.
Study of clinical and haematological profile of hereditary spherocytosis in Indian patients. The research describes age at presentation, family history, haemolytic crises, splenomegaly, osmotic fragility, and flow cytometry based diagnostic tests, and examines indications and outcomes of splenectomy.
Observational study of autoimmune haemolytic anaemia: clinical profile, immunohematological characteristics, and short term outcomes. This project evaluates warm and cold antibody mediated haemolysis, direct antiglobulin test patterns, underlying diseases, treatment regimens, and response to corticosteroids and second line therapy.
Study of prevalence and spectrum of beta thalassemia and related haemoglobinopathies in patients referred for evaluation of anaemia. The thesis uses high performance liquid chromatography to characterise haemoglobin variants, correlates findings with red cell indices and family history, and assesses awareness of carrier status among affected families.
Comparative study of transfusion dependent and non transfusion dependent thalassemia patients with respect to complications and quality of life. This research evaluates iron overload, endocrine complications, growth parameters, chelation therapy adherence, and patient reported quality of life in both groups.
Study of haemolytic anaemia in pregnancy: aetiology, maternal outcomes, and fetal outcomes. The project analyses causes such as autoimmune haemolysis, haemoglobinopathies, and microangiopathic haemolytic anaemia and correlates them with maternal morbidity, need for transfusion, and neonatal outcomes.
Cross sectional study of anaemia in elderly patients attending a tertiary care hospital. This thesis examines nutritional, renal, malignant, and chronic inflammatory causes of anaemia in older adults and evaluates the contribution of multiple overlapping aetiologies to overall anaemia burden.
Observational study of red cell morphology on peripheral smear and its concordance with automated cell counter generated indices. The research assesses agreement between manual smear review and automated parameters for microcytosis, macrocytosis, anisopoikilocytosis, and flags, and evaluates the added value of expert smear reporting in diagnosis.

2. White Cell Disorders including Leukocytosis, Neutropenia, and Rare White Cell Abnormalities

Cross sectional study of causes of leukocytosis in adult inpatients and correlation with final diagnosis. This project categorises leukocytosis into reactive and clonal causes, examines degree and pattern of white cell elevation, and correlates initial counts with eventual diagnoses and outcomes.
Observational study of severe neutropenia in adults: aetiology, infectious complications, and short term outcomes. The thesis evaluates drug induced, autoimmune, nutritional, malignant, and idiopathic causes of neutropenia, documents infectious events, and analyses predictors of poor outcome in neutropenic patients.
Study of clinical relevance of peripheral smear review in patients with leucopenia detected on automated blood counts. This research analyses smear findings such as dysplasia, blasts, left shift, and toxic granulation and assesses their role in guiding further investigations for bone marrow disorders.
Comparative study of infection patterns in patients with chronic neutropenia and those with normal neutrophil counts. The project evaluates frequency, site, severity, and microbiological spectrum of infections and examines use of prophylactic antibiotics and granulocyte colony stimulating factor in chronic neutropenia.
Study of eosinophilia in a tertiary care hospital: clinical spectrum, aetiology, and associated organ involvement. This thesis categorises parasitic, allergic, autoimmune, malignant, and idiopathic causes of eosinophilia and examines associated cardiac, pulmonary, and gastrointestinal involvement.
Observational study of monocytosis and its association with chronic infections and haematological malignancies. The research evaluates duration and degree of monocytosis, underlying causes such as tuberculosis and chronic myelomonocytic leukemia, and diagnostic yield of bone marrow examination in persistent cases.
Study of congenital and inherited neutrophil function disorders in children presenting with recurrent infections. This project examines clinical features, basic neutrophil function tests where available, genetic counselling, and outcomes in children with suspected neutrophil function defects.
Cross sectional analysis of white cell flagging patterns on automated analysers and their correlation with manual microscopy. The thesis evaluates accuracy of flags for blasts, immature granulocytes, and atypical lymphocytes in triggering morphology review in a busy hematology laboratory.
Study of lymphocytosis in adults with emphasis on distinction between reactive and clonal lymphoproliferative disorders. The research uses clinical features, smear morphology, flow cytometry, and bone marrow findings to classify lymphocytosis and develops an approach to evaluation in resource limited settings.
Observational study of haematological abnormalities in patients living with human immunodeficiency virus infection and acquired immunodeficiency syndrome. This project documents anaemia, leukopenia, thrombocytopenia, and combined cytopenias and correlates them with disease stage, opportunistic infections, and antiretroviral therapy.

3. Platelet Disorders and Coagulation Disorders

Cross sectional study of thrombocytopenia in medical inpatients and its underlying aetiology. This thesis categorises thrombocytopenia into immune mediated, infection related, drug induced, marrow failure, and hypersplenism related causes and examines bleeding manifestations and outcomes.
Study of immune thrombocytopenic purpura in adults: clinical profile, treatment response, and relapse patterns. The project evaluates initial platelet counts, bleeding severity, response to corticosteroids and second line agents, and predictors of chronic immune thrombocytopenic purpura.
Observational study of thrombocytopenia in pregnancy and its impact on maternal and fetal outcomes. This research analyses gestational thrombocytopenia, immune causes, preeclampsia related microangiopathy, and other aetiologies and examines bleeding risk, mode of delivery, and neonatal platelet counts.
Study of von Willebrand disease: clinical presentation, laboratory diagnosis, and subtype distribution. The thesis evaluates bleeding history, family history, screening tests, specialised assays for von Willebrand factor, and classifies patients into type one, type two, and type three disease in a tertiary centre.
Comparative study of bleeding scores and laboratory parameters in predicting clinically significant bleeding in inherited bleeding disorders. This project correlates standardised bleeding assessment tool scores with factor levels, platelet defects, and actual bleeding events in patients with inherited haemorrhagic conditions.
Study of coagulation abnormalities in chronic liver disease and their association with bleeding and thrombosis. The research evaluates prothrombin time, activated partial thromboplastin time, platelet count, fibrinogen, and global assays where available, and correlates them with clinical bleeding and venous thromboembolism.
Observational study of disseminated intravascular coagulation in critically ill patients. This thesis documents sepsis, malignancy, obstetric complications, and trauma as triggers, evaluates scoring systems for disseminated intravascular coagulation, and examines outcomes associated with coagulopathy severity.
Study of laboratory and clinical profile of inherited platelet function disorders in patients with mucocutaneous bleeding. The project evaluates bleeding time or platelet function analyser results, light transmission aggregometry where feasible, and family history to identify inherited platelet function defects.
Cross sectional analysis of anticoagulant use and quality of anticoagulation control in patients on long term therapy. This research examines indications, international normalised ratio control, time in therapeutic range, bleeding events, and thrombotic events in patients on vitamin K antagonists and newer oral anticoagulants.
Study of venous thromboembolism in hospitalised medical and surgical patients: risk factors, prophylaxis practices, and outcomes. The thesis evaluates adherence to thromboprophylaxis guidelines, identifies high risk patients, and correlates prophylaxis practices with incidence of deep vein thrombosis and pulmonary embolism.

4. Acute Leukemias including Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia

Study of clinical, morphological, and cytogenetic profile of acute myeloid leukemia (AML) in adults. This project describes presenting symptoms, organomegaly, blood and marrow morphology, cytochemical features, cytogenetic and molecular subtypes where available, and their distribution in an Indian cohort of AML.
Observational study of treatment response and early mortality in adults with acute myeloid leukemia receiving standard induction chemotherapy. The thesis evaluates complete remission rates, induction deaths, infectious complications, and risk factors predicting poor early outcome in AML patients treated at a tertiary care centre.
Study of minimal residual disease assessment in acute lymphoblastic leukemia (ALL) and its impact on risk stratification. This research evaluates flow cytometry based minimal residual disease at defined time points, correlates results with conventional risk factors, and assesses how minimal residual disease influences treatment decisions and outcomes in ALL.
Comparative study of adolescent and young adult acute lymphoblastic leukemia and paediatric acute lymphoblastic leukemia in a single centre. The project compares biology, treatment protocols, tolerability, and outcomes in adolescent and young adult patients versus younger children treated over the same period.
Study of clinical significance of hyperleukocytosis in acute leukemia with respect to complications and early outcomes. This thesis evaluates incidence of leukostasis, tumour lysis syndrome, disseminated intravascular coagulation, and early death in patients presenting with very high white cell counts in acute leukemia.
Observational study of acute promyelocytic leukemia: clinical presentation, coagulopathy, and treatment outcomes. The research describes haemorrhagic manifestations, laboratory evidence of coagulopathy, differentiation syndrome, and remission and survival rates after all trans retinoic acid based therapy.
Study of central nervous system involvement in acute lymphoblastic leukemia at diagnosis and during follow up. This project evaluates cerebrospinal fluid findings, risk factors for central nervous system disease, prophylactic strategies, and neurological outcomes in ALL patients.
Cross sectional study of expression of selected immunophenotypic markers and their correlation with risk categories in acute leukemia. The thesis uses flow cytometry to study aberrant antigen expression and correlates patterns with cytogenetic risk groups and response to induction therapy.
Study of tumour lysis syndrome in acute leukemia: incidence, risk factors, and impact on early mortality. The research evaluates laboratory and clinical tumour lysis syndrome, prophylactic measures such as hydration and uric acid lowering agents, and associated renal complications.
Observational study of quality of life in children and adults during maintenance therapy for acute lymphoblastic leukemia. This project uses validated quality of life questionnaires to assess physical, emotional, and social functioning and examines factors associated with impaired quality of life during long term therapy.

5. Chronic Leukemias and Myeloproliferative Neoplasms

Study of clinical and laboratory profile of chronic myeloid leukemia (CML) in a tertiary care centre. This thesis describes phases of CML at presentation, spleen size, blood counts, Sokal or other risk scores, and baseline molecular levels in patients starting tyrosine kinase inhibitor therapy.
Observational study of treatment response and adherence in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitor therapy. The project evaluates haematological, cytogenetic, and molecular responses, adverse effects, missed doses, and factors influencing adherence and long term outcomes in CML.
Study of chronic lymphocytic leukemia (CLL): clinical profile, immunophenotype, and prognostic markers. This research examines stage at diagnosis, lymph node burden, immunophenotypic profile, selected prognostic markers where feasible, and initial treatment strategies in CLL.
Cross sectional study of BCR-ABL negative myeloproliferative neoplasms including polycythaemia vera, essential thrombocythaemia, and primary myelofibrosis. The thesis documents clinical features, thrombotic and haemorrhagic events, bone marrow morphology, and driver mutation status where available in these myeloproliferative neoplasms.
Study of thrombotic complications in myeloproliferative neoplasms and associated risk factors. This project analyses arterial and venous thrombosis, identifies clinical and laboratory predictors, and evaluates impact of cytoreductive therapy and antiplatelet agents on events.
Observational study of transformation to acute leukemia or myelofibrosis in patients with chronic myeloproliferative neoplasms. The research examines time to transformation, preceding clinical features, laboratory changes, and outcomes after progression.
Study of prognostic scoring systems in chronic lymphocytic leukemia and their performance in an Indian cohort. This thesis applies standard risk scores to local patients and correlates risk categories with treatment requirement and survival outcomes.
Observational study of health related quality of life in patients with chronic myeloid leukemia on long term tyrosine kinase inhibitor therapy. The project uses validated questionnaires to assess functional status, symptom burden, financial toxicity, and psychosocial issues in patients on prolonged treatment.
Study of bone marrow fibrosis in chronic myeloproliferative neoplasms: grading, clinical correlates, and impact on outcome. This research evaluates marrow fibrosis grades on biopsy, correlates them with blood counts, spleen size, and symptom burden, and examines their prognostic significance.
Cross sectional analysis of splenomegaly in chronic leukemias and myeloproliferative neoplasms. The thesis assesses severity of splenomegaly, its association with symptoms, cytopenias, and therapeutic interventions including splenectomy or splenic irradiation.

6. Lymphomas including Hodgkin Lymphoma and Non Hodgkin Lymphoma

Study of clinical and histopathological profile of Hodgkin lymphoma in a tertiary care centre. This thesis examines age distribution, stage at diagnosis, histological subtypes, presence of B symptoms, and baseline laboratory parameters in patients with Hodgkin lymphoma.
Observational study of treatment response and early outcomes in classical Hodgkin lymphoma treated with standard chemotherapy regimens. The project evaluates complete and partial response rates, treatment related toxicities, relapse patterns, and short term survival in Hodgkin lymphoma.
Study of clinicopathological spectrum of non Hodgkin lymphoma in adult patients. This research describes nodal and extranodal presentations, histological subtypes, immunophenotype, stage distribution, and prognostic indices in non Hodgkin lymphoma.
Cross sectional analysis of extranodal non Hodgkin lymphoma with emphasis on gastrointestinal and other common extranodal sites. The thesis evaluates clinical presentation, imaging and endoscopic findings, histopathology, and outcomes in extranodal lymphomas.
Study of prognostic value of the International Prognostic Index and other scoring systems in diffuse large B cell lymphoma. This project applies prognostic indices to patients with diffuse large B cell lymphoma and correlates risk categories with treatment response and survival.
Observational study of central nervous system prophylaxis practices in high risk non Hodgkin lymphoma and associated outcomes. The research evaluates indications for prophylaxis, methods used, incidence of central nervous system relapse, and treatment related neurotoxicity.
Study of infection patterns and febrile neutropenia in patients receiving chemotherapy for lymphoma. This thesis documents febrile episodes, causative organisms, antimicrobial use, risk factors for severe infections, and impact on chemotherapy delivery.
Cross sectional study of quality of life in lymphoma survivors who have completed chemotherapy. The project uses validated tools to assess physical, emotional, and social wellbeing and examines persistent symptoms and psychosocial concerns after completion of therapy.
Study of bone marrow involvement in Hodgkin lymphoma and non Hodgkin lymphoma: frequency, patterns, and clinical correlates. This research evaluates bone marrow biopsy findings, correlation with stage, cytopenias, and impact on staging and prognosis.
Observational analysis of primary mediastinal and other rare lymphoma subtypes managed in a tertiary care centre. The thesis describes clinical features, treatment regimens, response rates, and challenges in diagnosis and management of rare lymphoma entities.

7. Multiple Myeloma and Plasma Cell Dyscrasias

Study of clinical and laboratory profile of newly diagnosed multiple myeloma. This project documents bone pain, anaemia, renal dysfunction, hypercalcaemia, monoclonal protein patterns, bone marrow plasma cell percentage, and staging in patients with multiple myeloma.
Observational study of response to first line therapy and early outcomes in multiple myeloma patients treated at a tertiary care centre. The thesis evaluates response rates, depth of response, treatment related toxicity, and progression free survival in patients receiving contemporary induction regimens.
Study of bone disease in multiple myeloma: radiological patterns, fracture risk, and impact of bisphosphonate therapy. This research examines lytic lesions, vertebral fractures, skeletal related events, and effectiveness of bisphosphonates in reducing pain and fracture risk.
Cross sectional analysis of renal involvement in multiple myeloma: clinical presentation, biopsy findings where available, and outcome. The thesis evaluates spectrum of renal dysfunction, contributors such as light chain cast nephropathy, and association of renal recovery with overall prognosis.
Study of monoclonal gammopathy of undetermined significance and smouldering myeloma: clinical features and risk of progression. This project follows patients with monoclonal gammopathy of undetermined significance and smouldering myeloma and tracks progression to symptomatic myeloma over time.
Observational study of infections in multiple myeloma patients on therapy. The research documents bacterial, viral, and fungal infections, vaccination status, use of prophylactic antibiotics, and associated morbidity and mortality.
Study of health related quality of life in patients with multiple myeloma receiving long term therapy. This thesis assesses fatigue, pain, functional status, emotional wellbeing, and treatment burden using validated quality of life instruments.
Study of light chain amyloidosis in patients presenting to a hematology service. The project evaluates organ involvement, diagnostic methods including tissue biopsy and special staining, treatment protocols, and outcomes in systemic light chain amyloidosis.
Cross sectional study of cytogenetic and molecular abnormalities in multiple myeloma and their correlation with risk stratification. This research reports frequencies of high risk abnormalities where available and evaluates their association with response to therapy and survival.
Observational analysis of supportive care practices in multiple myeloma including infection prophylaxis, thromboprophylaxis, and bone health. The thesis examines adherence to supportive care guidelines and association with treatment related complications and quality of life.

8. Bone Marrow Failure Syndromes and Aplastic Anaemia

Study of clinical and haematological profile of aplastic anaemia in a tertiary care hospital. This thesis describes severity grading, cytopenia patterns, bone marrow cellularity, and suspected aetiologies in patients diagnosed with aplastic anaemia.
Observational study of response to immunosuppressive therapy in aplastic anaemia and factors predicting outcome. The project evaluates response rates, time to response, relapse, clonal evolution, and complications in patients receiving antithymocyte globulin and cyclosporine or related regimens.
Study of inherited bone marrow failure syndromes presenting to a hematology unit. This research examines clinical features, physical anomalies, family history, bone marrow findings, and genetic testing where available in suspected inherited marrow failure syndromes.
Cross sectional study of pancytopenia in adults and its underlying causes. The thesis evaluates nutritional deficiencies, aplastic anaemia, haematological malignancies, hypersplenism, infections, and other causes of pancytopenia based on bone marrow examination and ancillary tests.
Study of myelodysplastic syndromes: clinical, morphological, and cytogenetic characteristics and prognostic scoring. This project evaluates cytopenias, dysplastic changes, blast percentage, cytogenetic abnormalities where available, and applies prognostic scoring systems for myelodysplastic syndromes.
Observational study of evolution from aplastic anaemia or myelodysplastic syndrome to acute myeloid leukemia. The research analyses incidence, time to transformation, warning signs, and outcomes in patients progressing to acute myeloid leukemia from marrow failure syndromes.
Study of infections and bleeding complications in patients with severe aplastic anaemia awaiting definitive therapy. This thesis documents incidence and severity of infections and haemorrhagic episodes and evaluates interim supportive care practices in these patients.
Cross sectional analysis of nutritional and socioeconomic factors in patients presenting with marrow failure. The project examines potential contributions of malnutrition, environmental exposures, and access to healthcare to the development and course of marrow failure syndromes.
Study of bone marrow trephine biopsy utility in differentiating aplastic anaemia from hypoplastic myelodysplastic syndrome. This research evaluates morphological features, fibrosis, and dysplasia on trephine biopsy and correlates them with clinical features and follow up.
Observational study of growth and development in children with bone marrow failure syndromes receiving long term therapy. The thesis examines height, weight, pubertal development, school attendance, and quality of life in children on chronic immunosuppressive or supportive treatment.

9. Transfusion Medicine and Apheresis in Hematology Practice

Cross sectional study of red cell transfusion practices in haematology inpatients. This thesis evaluates pre transfusion haemoglobin levels, indications, choice of blood components, adherence to restrictive transfusion thresholds, and documentation quality.
Study of alloimmunisation in multi transfused patients with thalassemia and other chronic anaemias. The project analyses frequency and specificity of red cell alloantibodies, risk factors for alloimmunisation, and implications for transfusion support.
Observational study of transfusion reactions in a hematology ward and day care setting. This research documents acute and delayed transfusion reactions, clinical features, laboratory workup, implicated components, and preventive measures.
Study of platelet transfusion practices and refractoriness in haemato oncology patients. The thesis evaluates indications, dose, transfusion intervals, platelet count increments, and immunological or non immunological causes of poor response to platelet transfusion.
Study of therapeutic plasma exchange in various haematological and non haematological indications managed by a hematology service. This project examines indications such as thrombotic microangiopathy and autoimmune disorders, number of procedures, complications, and clinical outcomes after plasma exchange.
Observational analysis of leukapheresis for hyperleukocytosis in acute leukemia. The research evaluates timing, efficacy in reducing white cell counts, procedure related complications, and impact on early outcomes in patients with hyperleukocytosis.
Study of donor deferral patterns in voluntary blood donors attending a teaching hospital blood centre. This thesis analyses reasons for deferral, temporary and permanent deferrals, and strategies to improve donor selection and recruitment.
Cross sectional study of knowledge and attitudes towards blood donation among relatives of haematology patients. The project assesses awareness, misconceptions, and willingness to donate blood and explores interventions to increase voluntary donation.
Study of appropriateness of fresh frozen plasma and cryoprecipitate transfusion in a tertiary care hospital. This research evaluates indications against established guidelines, assesses overuse and underuse, and suggests measures to rationalise plasma component usage.
Observational study of transfusion transmitted infection marker prevalence in blood donors and its trend over time. The thesis examines seroprevalence of major transfusion transmitted infections, screening strategies, and implications for blood safety.

10. Stem Cell Transplantation and Cellular Therapies

Observational study of indications and early outcomes of allogeneic haematopoietic stem cell transplantation in a tertiary care centre. This thesis documents underlying diseases, donor types, conditioning regimens, engraftment, acute graft versus host disease, infections, and early survival after transplantation.
Study of autologous haematopoietic stem cell transplantation in multiple myeloma and lymphoma. The project evaluates patient selection, mobilisation success, transplant related toxicity, disease response, and progression free survival after autologous transplantation.
Study of graft versus host disease: incidence, risk factors, and outcomes after allogeneic stem cell transplantation. This research examines clinical grading, organ involvement, prophylaxis regimens, and impact of acute and chronic graft versus host disease on survival and quality of life.
Cross sectional analysis of infections in the first one hundred days after haematopoietic stem cell transplantation. The thesis describes bacterial, viral, and fungal infections, risk factors, prophylactic strategies, and their contribution to early post transplant morbidity and mortality.
Study of quality of life and functional recovery in survivors of haematopoietic stem cell transplantation. This project uses validated tools to assess physical, emotional, social, and role functioning in transplant survivors at defined time points after transplantation.
Observational study of haematopoietic stem cell mobilisation strategies and their efficacy in autologous transplantation. The research compares granulocyte colony stimulating factor alone with chemotherapy plus granulocyte colony stimulating factor and documents collection yields, failures, and complications.
Study of long term endocrine and metabolic complications in haematopoietic stem cell transplant survivors. This thesis evaluates growth disturbances, thyroid dysfunction, gonadal failure, metabolic syndrome, and bone health issues in long term survivors.
Study of caregiver burden and psychosocial issues in families of patients undergoing stem cell transplantation. The project assesses emotional distress, financial strain, coping mechanisms, and support needs among caregivers using structured questionnaires.
Observational analysis of outcomes of haploidentical stem cell transplantation compared with matched related donor transplantation. This research compares engraftment, graft versus host disease, infections, relapse, and survival in patients undergoing haploidentical versus matched related donor transplantation where feasible.
Study of awareness and attitudes towards cellular therapies and stem cell transplantation among patients with haematological malignancies. The thesis evaluates patients’ understanding of transplant options, expectations, concerns, and decision making processes, and identifies gaps in counselling and information delivery.
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