Cardiology Thesis Topics

Cardiology Thesis Topics

Cardiology is a broad and rapidly evolving superspeciality that covers coronary artery disease, heart failure, arrhythmias, valvular heart disease, congenital heart disease, preventive cardiology, and advanced cardiac imaging and interventions. This page provides a structured, search engine optimised list of one hundred practical and clinically relevant cardiology thesis topics suitable for Doctorate of Medicine and equivalent superspeciality trainees in India. Topics include comparative, cross sectional, and observational designs and are chosen to be feasible in Indian tertiary care institutes while still having strong potential for publication and future academic work.

1. Coronary Artery Disease and Acute Coronary Syndromes

Comparative study of clinical profile and in hospital outcomes in patients with ST segment elevation myocardial infarction and non ST segment elevation acute coronary syndrome. This study compares demographic patterns, risk factor profiles, time to presentation, in hospital complications, and short term mortality between patients presenting with ST segment elevation myocardial infarction and non ST segment elevation acute coronary syndrome in a tertiary care cardiac centre.
Prospective observational study of door to balloon time and its association with mortality in patients undergoing primary percutaneous coronary intervention. The thesis evaluates each component of delay from symptom onset to reperfusion, identifies modifiable system related factors, and correlates total ischaemic time with left ventricular function and in hospital outcomes.
Study of the impact of diabetes mellitus on clinical presentation and short term outcomes in acute coronary syndrome. This project compares symptom patterns, extent of coronary artery disease, thrombus burden, and incidence of heart failure, arrhythmias, and mortality between diabetic and non diabetic patients admitted with acute coronary syndrome.
Cross sectional analysis of high sensitivity cardiac troponin and electrocardiographic changes in early diagnosis of acute coronary syndrome in Indian patients. The research assesses diagnostic performance of high sensitivity troponin assays in combination with serial electrocardiograms and evaluates their role in rapid rule in and rule out strategies for chest pain in the emergency department.
Comparative evaluation of clinical outcomes in young adults and older adults presenting with acute coronary syndrome. This thesis contrasts risk factors, angiographic patterns, treatment strategies, and in hospital complications in patients younger than forty years compared to those in older age groups presenting with acute coronary syndrome.
Prospective observational study of Killip class at presentation as a predictor of short term mortality in acute myocardial infarction. The project examines the relationship between heart failure severity at admission, use of evidence based therapies, and thirty day mortality in patients with acute myocardial infarction in a resource constrained Indian setting.
Study of gender differences in presentation and management of acute coronary syndrome. This research analyses delays in seeking care, atypical symptoms, choice of reperfusion strategy, and adherence to guideline directed therapies among women compared to men with acute coronary syndrome.
Cross sectional study of lipid profile patterns and their association with angiographic severity in patients with chronic stable angina. The thesis evaluates whether specific lipid abnormalities such as elevated triglycerides or low high density lipoprotein cholesterol are associated with more extensive or complex coronary artery disease.
Observational study of the relationship between admission blood pressure and in hospital outcomes in acute coronary syndrome. This project explores whether low, normal, or high blood pressure at presentation is associated with increased risk of heart failure, cardiogenic shock, arrhythmias, or mortality.
Study of anaemia as a prognostic marker in patients admitted with acute coronary syndrome. The research evaluates the prevalence of anaemia, its association with bleeding, transfusion requirements, and adverse outcomes, and examines whether correction of anaemia influences short term prognosis.

2. Interventional Cardiology and Percutaneous Coronary Procedures

Comparative study of radial and femoral arterial access in elective percutaneous coronary intervention. This thesis compares procedural success, vascular complications, bleeding events, contrast usage, fluoroscopy time, and patient comfort and ambulation between radial and femoral access in routine coronary interventions.
Prospective observational study of contrast induced acute kidney injury in patients undergoing coronary angiography and percutaneous coronary intervention. The project evaluates incidence of acute kidney injury, identifies risk factors including baseline renal function and contrast volume, and examines preventive strategies such as hydration and use of low osmolality contrast media.
Study of clinical and angiographic predictors of no reflow phenomenon following primary percutaneous coronary intervention. The research analyses thrombus burden, lesion characteristics, procedural variables, and inflammatory markers that are associated with suboptimal myocardial reperfusion despite successful epicardial artery opening.
Comparative evaluation of outcomes with drug eluting stents and bare metal stents in an Indian tertiary care setting. This thesis compares rates of restenosis, stent thrombosis, need for target lesion revascularisation, and major adverse cardiac events over one year after implantation of the two stent types.
Cross sectional study of appropriateness criteria application in diagnostic coronary angiography. The project evaluates indications for coronary angiography and assesses alignment with standard appropriateness guidelines, aiming to identify patterns of overuse or underuse in daily practice.
Observational study of periprocedural myocardial infarction in non emergency percutaneous coronary intervention. The research determines incidence of biomarker elevation after elective procedures, relates it to procedural complexity, and examines its association with subsequent adverse events.
Comparative study of transradial percutaneous coronary intervention in obese and non obese patients. This thesis evaluates technical difficulty, success rates, bleeding complications, and radiation exposure in patients with high body mass index compared to normal weight individuals.
Study of clinical outcomes after percutaneous coronary intervention for chronic total occlusions in a tertiary care centre. The project analyses procedural success, complications, symptom relief, and improvement in left ventricular function following intervention on chronic total occlusions.
Observational study of emergency coronary angiography and percutaneous coronary intervention in patients with cardiogenic shock. The research evaluates feasibility, use of mechanical circulatory support, complications, and in hospital mortality in patients with cardiogenic shock undergoing urgent invasive management.
Comparative evaluation of various risk scores in predicting outcomes after percutaneous coronary intervention. This thesis compares predictive accuracy of widely used procedural risk scores for in hospital and short term adverse events in patients undergoing coronary interventions.

3. Heart Failure and Cardiomyopathies

Prospective observational study of clinical profile and short term outcomes in patients with acute decompensated heart failure. The project describes precipitating factors, adherence to guideline directed medical therapy, in hospital management strategies, and predictors of mortality and readmission in patients admitted with acute heart failure.
Comparative analysis of heart failure with reduced ejection fraction and heart failure with preserved ejection fraction in an Indian tertiary care hospital. This thesis compares demographics, comorbidities, echocardiographic characteristics, natriuretic peptide levels, and outcomes in patients with reduced and preserved ejection fraction.
Study of the association between serum natriuretic peptides and left ventricular function in chronic heart failure. The project evaluates how levels of brain natriuretic peptide or N terminal pro brain natriuretic peptide correlate with echocardiographic parameters and New York Heart Association functional class.
Observational study of adherence to guideline directed medical therapy in heart failure with reduced ejection fraction and its impact on outcomes. This research examines prescription patterns, dose optimisation, and patient adherence to angiotensin converting enzyme inhibitors, beta blockers, mineralocorticoid receptor antagonists, and newer agents, and relates them to hospitalisation and survival.
Cross sectional study of iron deficiency and anaemia in patients with chronic heart failure. The thesis determines prevalence of iron deficiency, investigates its association with functional capacity and quality of life, and evaluates patterns of intravenous or oral iron therapy.
Study of echocardiographic and clinical characteristics of dilated cardiomyopathy in Indian patients. This project describes aetiology, familial patterns, chamber dimensions, and arrhythmic burden, and examines prognostic factors in dilated cardiomyopathy.
Prospective study of hypertrophic cardiomyopathy with emphasis on risk stratification for sudden cardiac death. The research evaluates clinical, echocardiographic, electrocardiographic, and genetic markers that contribute to risk assessment and decisions regarding implantable cardioverter defibrillator therapy.
Observational analysis of chemotherapy induced cardiomyopathy in patients receiving cancer treatment. This thesis tracks left ventricular function, biomarkers, and symptoms in patients exposed to potentially cardiotoxic chemotherapy and explores early detection strategies and cardioprotective measures.
Study of quality of life and functional capacity in patients with chronic heart failure using validated questionnaires and six minute walk test. The project evaluates how clinical status, comorbidities, and therapy optimisation influence patient reported outcomes and exercise capacity.
Comparative study of outcomes in patients with heart failure receiving optimised medical therapy alone versus those receiving device based therapy such as cardiac resynchronisation. This research compares clinical improvement, hospitalisation rates, and survival in patients treated with medication alone versus those undergoing cardiac resynchronisation therapy where indicated.

4. Cardiac Electrophysiology and Arrhythmias

Prospective observational study of atrial fibrillation in a tertiary care hospital. The thesis describes clinical profile, underlying cardiac and non cardiac conditions, treatment strategies including rate control and rhythm control, and short term outcomes in patients with atrial fibrillation.
Study of risk factors for stroke in patients with non valvular atrial fibrillation using standard risk scores. This project applies established stroke risk scoring systems to local patients and correlates risk categories with actual occurrence of stroke and systemic embolism.
Comparative study of rate control and rhythm control strategies in patients with symptomatic atrial fibrillation. The research evaluates symptom burden, quality of life, exercise tolerance, and hospitalisation rates in patients managed primarily with rate control versus those undergoing rhythm control interventions.
Observational study of ventricular arrhythmias in patients with structural heart disease. This thesis documents types and frequency of ventricular arrhythmias, associated structural abnormalities, and use of implantable cardioverter defibrillator therapy or catheter ablation.
Study of sudden cardiac arrest survivors and their long term outcomes after implantable cardioverter defibrillator implantation. The project examines recurrence of arrhythmias, device therapies delivered, psychological impact, and quality of life in survivors of sudden cardiac arrest.
Cross sectional study of conduction disturbances and atrioventricular block in a cardiology department. This research describes etiologies, temporary and permanent pacing indications, and outcomes in patients with varying degrees of atrioventricular block.
Observational study of catheter ablation outcomes in patients with supraventricular tachycardia. The thesis evaluates acute success, complications, recurrence of tachycardia, and symptom improvement after ablation procedures for common supraventricular arrhythmias.
Study of corrected QT interval and associated clinical factors in hospitalised cardiac patients. This project evaluates the prevalence of prolonged corrected QT interval, associated medications and electrolyte disturbances, and risk of torsades de pointes and sudden death.
Comparative study of antiarrhythmic drug therapy and catheter ablation in symptomatic atrial flutter. The research compares long term maintenance of sinus rhythm, quality of life, and adverse effects between pharmacological treatment and radiofrequency ablation.
Observational analysis of complications and outcomes of temporary transvenous pacing in an Indian tertiary care hospital. This thesis documents indications for temporary pacing, access routes used, complications such as infection and lead dislodgement, and in hospital outcomes.

5. Valvular Heart Diseases

Cross sectional study of rheumatic valvular heart disease in adult patients in a tertiary care centre. The project describes the prevalence of isolated and combined valve lesions, clinical presentation, echocardiographic features, and association with atrial fibrillation and heart failure.
Study of degenerative aortic stenosis and its clinical, echocardiographic, and prognostic characteristics. This thesis evaluates symptom status, valve area, gradient, left ventricular function, and short term outcomes in patients with degenerative aortic stenosis.
Comparative analysis of clinical outcomes after valve replacement with mechanical and bioprosthetic valves. The research compares anticoagulation requirements, thromboembolic and bleeding complications, structural valve deterioration, and survival in patients receiving mechanical versus biological valves.
Study of pulmonary hypertension in patients with chronic rheumatic mitral valve disease. This project evaluates prevalence and severity of pulmonary hypertension, its relationship to symptoms and functional capacity, and the impact of valve intervention on pulmonary pressures.
Prospective observational study of infective endocarditis and its short term outcomes. The thesis describes causative organisms, predisposing cardiac conditions, complications such as heart failure and embolism, and indications for surgical intervention in infective endocarditis.
Comparative study of percutaneous balloon mitral valvotomy and surgical mitral valve replacement in rheumatic mitral stenosis. This research assesses procedural success, complications, improvement in valve area and symptoms, and medium term outcomes between the two treatment strategies.
Study of anticoagulation control and complications in patients with mechanical prosthetic heart valves. The project evaluates time in therapeutic range, patient education, and incidence of thromboembolic and bleeding events in relation to anticoagulation quality.
Observational study of tricuspid regurgitation in patients with left sided valvular disease. The thesis examines mechanisms, severity, and clinical impact of tricuspid regurgitation and outcomes after surgical or medical management of the primary lesion.
Cross sectional evaluation of functional mitral regurgitation in dilated cardiomyopathy. This research analyses relationship between left ventricular dilatation, mitral annular dimensions, regurgitation severity, and heart failure symptoms.
Study of left atrial function and dimensions as predictors of outcome in mitral valve disease. The project correlates left atrial size and functional indices with atrial fibrillation, stroke, and postoperative outcomes in patients undergoing valve surgery.

6. Hypertension and Vascular Disorders

Cross sectional study of awareness, treatment, and control of systemic hypertension in patients attending a cardiology outpatient clinic. The thesis evaluates how many patients are aware of their diagnosis, receiving treatment, and adequately controlled, and identifies barriers to optimal control.
Study of left ventricular hypertrophy patterns in patients with long standing systemic hypertension. This project characterises concentric and eccentric hypertrophy patterns on echocardiography and explores their association with risk factors and symptoms.
Observational study of resistant hypertension and secondary causes in patients referred to a tertiary care cardiology department. The research investigates prevalence of renal artery stenosis, endocrine causes, and medication non adherence in patients with uncontrolled blood pressure despite multiple drugs.
Comparative study of ambulatory blood pressure monitoring and office blood pressure measurements in diagnosis of hypertension. This thesis evaluates white coat and masked hypertension, and assesses the utility of ambulatory monitoring in guiding therapy decisions.
Study of hypertensive emergencies and urgencies in a tertiary care hospital. The project documents clinical presentations, target organ damage, treatment regimens, and short term outcomes in patients with very high blood pressure.
Observational analysis of aortic dilatation and aneurysm in patients with long standing systemic hypertension. This research evaluates prevalence of aortic root and ascending aorta dilatation using echocardiography and relates it to blood pressure control and associated conditions.
Study of peripheral arterial disease in patients with established coronary artery disease. The thesis uses ankle brachial index and duplex ultrasound to document peripheral arterial disease and correlates it with severity of coronary artery involvement and outcomes.
Cross sectional evaluation of carotid intima media thickness as a marker of subclinical atherosclerosis in hypertensive patients. This project assesses the relationship between carotid intima media thickness, blood pressure control, and other cardiovascular risk factors.
Study of pulmonary arterial hypertension in patients with systemic connective tissue diseases. The research evaluates prevalence, severity, and clinical correlates of pulmonary arterial hypertension using echocardiography and right heart catheterisation where available.
Observational study of adherence to lifestyle modification advice in patients with newly diagnosed hypertension. This thesis examines dietary changes, exercise, smoking cessation, and weight control, and their impact on blood pressure over follow up.

7. Cardiac Imaging including Echocardiography, Computed Tomography, and Magnetic Resonance Imaging

Cross sectional study of diastolic dysfunction in patients with systemic hypertension using echocardiography. The project evaluates grades of diastolic dysfunction, left atrial size, and their relationship with symptoms and blood pressure control.
Study of speckle tracking echocardiography derived global longitudinal strain in early detection of left ventricular dysfunction. This thesis examines patients with normal ejection fraction but suspected subclinical dysfunction, including those receiving cardiotoxic drugs and those with hypertension or diabetes mellitus.
Observational study of stress echocardiography in diagnosis of inducible myocardial ischaemia. The research compares stress echocardiogram results with coronary angiography where available and evaluates sensitivity, specificity, and clinical usefulness.
Study of right ventricular function by echocardiography in patients with pulmonary hypertension. This project evaluates right ventricular dimensions, fractional area change, tricuspid annular plane systolic excursion, and other indices in relation to functional status.
Comparative study of computed tomography coronary angiography and invasive coronary angiography in selected patients with suspected coronary artery disease. The thesis assesses accuracy, limitations, and impact on clinical decision making of computed tomography coronary angiography in comparison with invasive angiography.
Observational analysis of cardiac magnetic resonance imaging in cardiomyopathy evaluation. The research documents patterns of late gadolinium enhancement and tissue characterisation and correlates them with clinical diagnosis and prognosis.
Study of echocardiographic predictors of outcome in patients with severe aortic stenosis awaiting intervention. This project evaluates valve gradients, valve area, left ventricular function, and strain parameters in relation to symptom onset and adverse events.
Cross sectional study of pericardial diseases using echocardiography and computed tomography. The thesis describes effusive, constrictive, and mixed pericardial conditions and evaluates the role of multimodality imaging in diagnosis and management.
Study of echocardiographic screening for congenital heart disease in adults with unexplained murmurs. This research evaluates the yield of echocardiography in detecting previously unrecognised congenital lesions in adults presenting with cardiac murmurs.
Observational study of three dimensional echocardiography in assessment of mitral valve morphology before repair. The project examines how three dimensional imaging helps surgical planning and compares it with conventional two dimensional echocardiography.

8. Congenital Heart Disease in Children and Adults

Cross sectional study of the spectrum of congenital heart disease in children presenting to a tertiary care cardiology centre. The thesis documents prevalence of acyanotic and cyanotic lesions, age at diagnosis, and associated syndromes in paediatric patients.
Study of clinical and echocardiographic profile of adults with unrepaired congenital heart disease. This project examines natural history, complications, and quality of life in adults who reached maturity with unrepaired or partially treated congenital lesions.
Observational study of outcomes following device closure of atrial septal defects. The research evaluates procedural success, complications, improvement in symptoms, and right heart remodelling after percutaneous closure.
Study of pulmonary arterial hypertension associated with congenital heart disease. This thesis assesses severity of pulmonary hypertension, functional capacity, and impact of surgical or device closure on pulmonary pressures and symptoms.
Study of arrhythmias in adults with operated congenital heart disease. The project analyses prevalence of atrial and ventricular arrhythmias, risk factors, and need for electrophysiology interventions in this high risk population.
Comparative study of transcatheter device closure and surgical repair of patent ductus arteriosus. This research compares operative variables, complications, hospital stay, and cost between percutaneous and open approaches.
Observational analysis of quality of life in adolescents and adults with congenital heart disease using validated questionnaires. The thesis evaluates physical, emotional, and social functioning and identifies factors associated with impaired quality of life.
Study of infective endocarditis in patients with congenital heart disease. This project documents predisposing lesions, microbiology, complications, and outcomes in children and adults with congenital heart disease who develop infective endocarditis.
Cross sectional study of nutritional status in children with congenital heart disease. The research examines patterns and determinants of undernutrition and growth failure and their relationship to haemodynamic severity.
Study of pregnancy outcomes in women with congenital heart disease followed in a cardiology clinic. This thesis evaluates maternal and fetal outcomes, risk factors for complications, and adequacy of preconception and antenatal counselling.

9. Preventive Cardiology and Risk Stratification

Cross sectional study of cardiovascular risk factors in young adults attending a tertiary care hospital. The project assesses prevalence of smoking, obesity, dyslipidaemia, hypertension, and diabetes mellitus in individuals younger than forty years.
Study of adherence to lifestyle modification advice in patients with established coronary artery disease. This thesis evaluates diet, physical activity, smoking cessation, and stress management, and their effect on recurrent events and control of risk factors.
Observational study of metabolic syndrome in patients with first episode of acute coronary syndrome. The research documents prevalence of metabolic syndrome and examines its association with severity of coronary artery disease and short term outcomes.
Study of family history and genetic susceptibility markers in premature coronary artery disease. This project explores clustering of risk in families and evaluates selected genetic markers where feasible in young patients with coronary events.
Cross sectional evaluation of physical activity levels in patients with stable coronary artery disease using validated activity questionnaires. The thesis examines how many patients achieve recommended activity levels and identifies barriers to exercise.
Study of cardiovascular risk perception and understanding of risk factors in patients and their relatives. The project assesses knowledge, attitudes, and beliefs about risk factors and prevention among patients with established cardiovascular disease and their family members.
Observational analysis of statin use and lipid goal attainment in secondary prevention of coronary artery disease. This thesis evaluates prescription patterns, dose intensity, adherence, and achievement of recommended low density lipoprotein cholesterol targets.
Study of impact of a structured cardiac rehabilitation programme on functional capacity and quality of life after myocardial infarction. The research evaluates exercise tolerance, symptom burden, psychological wellbeing, and return to work after participation in a formal rehabilitation programme.
Cross sectional study of smoking cessation patterns and relapse in patients with coronary artery disease. This project documents counselling, pharmacological support, relapse rates, and associated factors in smokers after a coronary event.
Study of risk stratification using standard global cardiovascular risk calculators in an Indian outpatient population. The thesis applies global risk scores to local patients and compares calculated risk with observed prevalence of subclinical atherosclerosis.

10. Cardiac Critical Care and Post Procedural Management

Observational study of clinical profile and outcomes of patients admitted to a cardiac intensive care unit. The project describes spectrum of diagnoses, resource utilisation, length of stay, and mortality in a dedicated cardiac intensive care environment.
Study of sepsis and infection patterns in the cardiac intensive care unit. This thesis examines sources of infection, causative organisms, antimicrobial resistance, and risk factors specific to cardiac patients.
Prospective study of acute kidney injury in patients admitted to cardiac intensive care following cardiac surgery or interventional cardiology procedures. The research evaluates incidence, predictors, need for renal replacement therapy, and impact on short term outcomes.
Study of delirium in cardiac intensive care unit patients using validated assessment tools. This project assesses incidence of delirium, associated risk factors, and its relationship with length of stay and mortality.
Observational study of respiratory failure and need for non invasive and invasive ventilation in the cardiac intensive care unit. The thesis documents indications, success rates, and complications of ventilatory support in cardiac patients.
Study of outcomes of patients with cardiogenic shock managed in a cardiac intensive care unit. The research evaluates use of inotropes, vasopressors, mechanical circulatory support devices, and their association with short term survival.
Study of bleeding complications and blood product utilisation in post cardiac surgery patients in the intensive care unit. This project examines transfusion practices, risk factors for bleeding, and adherence to transfusion guidelines.
Cross sectional study of pain assessment and management in post procedural cardiac intensive care patients. The thesis evaluates adequacy of pain control, documentation of pain scores, and use of multimodal analgesia strategies.
Study of early mobilisation programmes in the cardiac intensive care unit and their feasibility and impact on outcomes. This research assesses safety, improvement in functional status, and length of hospital stay associated with structured mobilisation protocols.
Observational analysis of readmission to the cardiac intensive care unit after initial discharge to the ward. The project identifies causes, risk factors, and mortality associated with readmission, and explores opportunities for improving discharge criteria.
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